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The microbiological characteristics and risk factors for PICC-related bloodstream infections in intensive care unit
The study was aimed to investigate the pathogens distribution and risk factors for PICC-related bloodstream infection in intensive care unit (ICU) patients. 402 patients placed with PICC in ICU were recruited in the study. The microbiological characteristics of PICC-related infection were investigat...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678102/ https://www.ncbi.nlm.nih.gov/pubmed/29118410 http://dx.doi.org/10.1038/s41598-017-10037-2 |
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author | Zhang, Shumin Sun, Xiaofeng Lei, Yan |
author_facet | Zhang, Shumin Sun, Xiaofeng Lei, Yan |
author_sort | Zhang, Shumin |
collection | PubMed |
description | The study was aimed to investigate the pathogens distribution and risk factors for PICC-related bloodstream infection in intensive care unit (ICU) patients. 402 patients placed with PICC in ICU were recruited in the study. The microbiological characteristics of PICC-related infection were investigated by Vitek 2 Compact automated microbial system. Antibiotics sensitivity was performed with disk diffusion and minimum inhibitory concentration (MIC) methods. Multivariate logistic and cox analyses were performed to identify the risk factors for PICC-related infection in ICU patients. 38 PICC-related infection cases were observed, and its morbidity was 9.45%. The morbidity was significantly higher in power PICC cases than that in common PICC cases. Gram-positive bacteria might be responsible for the major infection cases, followed by gram-negative bacteria, and fungi. Drug sensitivity analyses indicated that gram-negative bacteria showed low resistance to carbapenems antibiotics, and Cefperazone/sulbactam. The gram-positive bacterial exhibited sensitive to Teicoplanin and Vancomycin. The isolated fungi showed low resistance to the commonly used antifungal antibiotics. Multivariate analyses demonstrated that power PICC, high Charison scores, diabetes mellitus, double lumens triple lumens were risk factors for PICC-related infections among ICU patients. Power PICC, high Charison scores, diabetes mellitus, multi-lumens are risk factors for PICC-related bloodstream infection in ICU patients. |
format | Online Article Text |
id | pubmed-5678102 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-56781022017-11-17 The microbiological characteristics and risk factors for PICC-related bloodstream infections in intensive care unit Zhang, Shumin Sun, Xiaofeng Lei, Yan Sci Rep Article The study was aimed to investigate the pathogens distribution and risk factors for PICC-related bloodstream infection in intensive care unit (ICU) patients. 402 patients placed with PICC in ICU were recruited in the study. The microbiological characteristics of PICC-related infection were investigated by Vitek 2 Compact automated microbial system. Antibiotics sensitivity was performed with disk diffusion and minimum inhibitory concentration (MIC) methods. Multivariate logistic and cox analyses were performed to identify the risk factors for PICC-related infection in ICU patients. 38 PICC-related infection cases were observed, and its morbidity was 9.45%. The morbidity was significantly higher in power PICC cases than that in common PICC cases. Gram-positive bacteria might be responsible for the major infection cases, followed by gram-negative bacteria, and fungi. Drug sensitivity analyses indicated that gram-negative bacteria showed low resistance to carbapenems antibiotics, and Cefperazone/sulbactam. The gram-positive bacterial exhibited sensitive to Teicoplanin and Vancomycin. The isolated fungi showed low resistance to the commonly used antifungal antibiotics. Multivariate analyses demonstrated that power PICC, high Charison scores, diabetes mellitus, double lumens triple lumens were risk factors for PICC-related infections among ICU patients. Power PICC, high Charison scores, diabetes mellitus, multi-lumens are risk factors for PICC-related bloodstream infection in ICU patients. Nature Publishing Group UK 2017-11-08 /pmc/articles/PMC5678102/ /pubmed/29118410 http://dx.doi.org/10.1038/s41598-017-10037-2 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Zhang, Shumin Sun, Xiaofeng Lei, Yan The microbiological characteristics and risk factors for PICC-related bloodstream infections in intensive care unit |
title | The microbiological characteristics and risk factors for PICC-related bloodstream infections in intensive care unit |
title_full | The microbiological characteristics and risk factors for PICC-related bloodstream infections in intensive care unit |
title_fullStr | The microbiological characteristics and risk factors for PICC-related bloodstream infections in intensive care unit |
title_full_unstemmed | The microbiological characteristics and risk factors for PICC-related bloodstream infections in intensive care unit |
title_short | The microbiological characteristics and risk factors for PICC-related bloodstream infections in intensive care unit |
title_sort | microbiological characteristics and risk factors for picc-related bloodstream infections in intensive care unit |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678102/ https://www.ncbi.nlm.nih.gov/pubmed/29118410 http://dx.doi.org/10.1038/s41598-017-10037-2 |
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