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Genome-wide Association Study of Idiopathic Osteonecrosis of the Femoral Head
Idiopathic osteonecrosis of the femoral head (IONFH) is an ischemic disorder that causes bone necrosis of the femoral head, resulting in hip joint dysfunction. IONFH is a polygenic disease and steroid and alcohol have already known to increase its risk; however, the mechanism of IONFH remains to be...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678103/ https://www.ncbi.nlm.nih.gov/pubmed/29118346 http://dx.doi.org/10.1038/s41598-017-14778-y |
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| author | Sakamoto, Yuma Yamamoto, Takuaki Sugano, Nobuhiko Takahashi, Daisuke Watanabe, Toshiyuki Atsumi, Takashi Nakamura, Junichi Hasegawa, Yukiharu Akashi, Koichi Narita, Ichiei Miyamoto, Takeshi Takeuchi, Tsutomu Ikari, Katsunori Amano, Koichi Fujie, Atsuhiro Kubo, Toshikazu Tada, Yoshifumi Kaneuji, Ayumi Nakamura, Hiroaki Miyamura, Tomoya Kabata, Tamon Yamaji, Ken Okawa, Takahiro Sudo, Akihiro Ohzono, Kenji Tanaka, Yoshiya Yasunaga, Yuji Matsuda, Shuichi Imai, Yuuki Akiyama, Masato Kubo, Michiaki Kamatani, Yoichiro Iwamoto, Yukihide Ikegawa, Shiro |
| author_facet | Sakamoto, Yuma Yamamoto, Takuaki Sugano, Nobuhiko Takahashi, Daisuke Watanabe, Toshiyuki Atsumi, Takashi Nakamura, Junichi Hasegawa, Yukiharu Akashi, Koichi Narita, Ichiei Miyamoto, Takeshi Takeuchi, Tsutomu Ikari, Katsunori Amano, Koichi Fujie, Atsuhiro Kubo, Toshikazu Tada, Yoshifumi Kaneuji, Ayumi Nakamura, Hiroaki Miyamura, Tomoya Kabata, Tamon Yamaji, Ken Okawa, Takahiro Sudo, Akihiro Ohzono, Kenji Tanaka, Yoshiya Yasunaga, Yuji Matsuda, Shuichi Imai, Yuuki Akiyama, Masato Kubo, Michiaki Kamatani, Yoichiro Iwamoto, Yukihide Ikegawa, Shiro |
| author_sort | Sakamoto, Yuma |
| collection | PubMed |
| description | Idiopathic osteonecrosis of the femoral head (IONFH) is an ischemic disorder that causes bone necrosis of the femoral head, resulting in hip joint dysfunction. IONFH is a polygenic disease and steroid and alcohol have already known to increase its risk; however, the mechanism of IONFH remains to be elucidated. We performed a genome-wide association study using ~60,000 subjects and found two novel loci on chromosome 20q12 and 12q24. Big data analyses identified LINC01370 as a candidate susceptibility gene in the 20q12 locus. Stratified analysis by IONFH risk factors suggested that the 12q24 locus was associated with IONFH through drinking capacity. Our findings would shed new light on pathophysiology of IONFH. |
| format | Online Article Text |
| id | pubmed-5678103 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2017 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-56781032017-11-17 Genome-wide Association Study of Idiopathic Osteonecrosis of the Femoral Head Sakamoto, Yuma Yamamoto, Takuaki Sugano, Nobuhiko Takahashi, Daisuke Watanabe, Toshiyuki Atsumi, Takashi Nakamura, Junichi Hasegawa, Yukiharu Akashi, Koichi Narita, Ichiei Miyamoto, Takeshi Takeuchi, Tsutomu Ikari, Katsunori Amano, Koichi Fujie, Atsuhiro Kubo, Toshikazu Tada, Yoshifumi Kaneuji, Ayumi Nakamura, Hiroaki Miyamura, Tomoya Kabata, Tamon Yamaji, Ken Okawa, Takahiro Sudo, Akihiro Ohzono, Kenji Tanaka, Yoshiya Yasunaga, Yuji Matsuda, Shuichi Imai, Yuuki Akiyama, Masato Kubo, Michiaki Kamatani, Yoichiro Iwamoto, Yukihide Ikegawa, Shiro Sci Rep Article Idiopathic osteonecrosis of the femoral head (IONFH) is an ischemic disorder that causes bone necrosis of the femoral head, resulting in hip joint dysfunction. IONFH is a polygenic disease and steroid and alcohol have already known to increase its risk; however, the mechanism of IONFH remains to be elucidated. We performed a genome-wide association study using ~60,000 subjects and found two novel loci on chromosome 20q12 and 12q24. Big data analyses identified LINC01370 as a candidate susceptibility gene in the 20q12 locus. Stratified analysis by IONFH risk factors suggested that the 12q24 locus was associated with IONFH through drinking capacity. Our findings would shed new light on pathophysiology of IONFH. Nature Publishing Group UK 2017-11-08 /pmc/articles/PMC5678103/ /pubmed/29118346 http://dx.doi.org/10.1038/s41598-017-14778-y Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| spellingShingle | Article Sakamoto, Yuma Yamamoto, Takuaki Sugano, Nobuhiko Takahashi, Daisuke Watanabe, Toshiyuki Atsumi, Takashi Nakamura, Junichi Hasegawa, Yukiharu Akashi, Koichi Narita, Ichiei Miyamoto, Takeshi Takeuchi, Tsutomu Ikari, Katsunori Amano, Koichi Fujie, Atsuhiro Kubo, Toshikazu Tada, Yoshifumi Kaneuji, Ayumi Nakamura, Hiroaki Miyamura, Tomoya Kabata, Tamon Yamaji, Ken Okawa, Takahiro Sudo, Akihiro Ohzono, Kenji Tanaka, Yoshiya Yasunaga, Yuji Matsuda, Shuichi Imai, Yuuki Akiyama, Masato Kubo, Michiaki Kamatani, Yoichiro Iwamoto, Yukihide Ikegawa, Shiro Genome-wide Association Study of Idiopathic Osteonecrosis of the Femoral Head |
| title | Genome-wide Association Study of Idiopathic Osteonecrosis of the Femoral Head |
| title_full | Genome-wide Association Study of Idiopathic Osteonecrosis of the Femoral Head |
| title_fullStr | Genome-wide Association Study of Idiopathic Osteonecrosis of the Femoral Head |
| title_full_unstemmed | Genome-wide Association Study of Idiopathic Osteonecrosis of the Femoral Head |
| title_short | Genome-wide Association Study of Idiopathic Osteonecrosis of the Femoral Head |
| title_sort | genome-wide association study of idiopathic osteonecrosis of the femoral head |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678103/ https://www.ncbi.nlm.nih.gov/pubmed/29118346 http://dx.doi.org/10.1038/s41598-017-14778-y |
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