Decreased absolute numbers of CD3(+) T cells and CD8(+) T cells during aging in herpes zoster patients

Herpes zoster (HZ) is an infectious dermatosis with high incidence worldwide. Age is a key risk factor for HZ, and postherpetic neuralgia (PHN) is the main sequelae. Until now, no index has been available to predict the pathogenesis of PHN, and rare reports have focused on the immune response during...

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Autores principales: Wei, Li, Zhao, Jianguang, Wu, Wei, Zhang, Yu, Fu, Xuyan, Chen, Lifeng, Wang, Xiaoting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678144/
https://www.ncbi.nlm.nih.gov/pubmed/29118328
http://dx.doi.org/10.1038/s41598-017-15390-w
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author Wei, Li
Zhao, Jianguang
Wu, Wei
Zhang, Yu
Fu, Xuyan
Chen, Lifeng
Wang, Xiaoting
author_facet Wei, Li
Zhao, Jianguang
Wu, Wei
Zhang, Yu
Fu, Xuyan
Chen, Lifeng
Wang, Xiaoting
author_sort Wei, Li
collection PubMed
description Herpes zoster (HZ) is an infectious dermatosis with high incidence worldwide. Age is a key risk factor for HZ, and postherpetic neuralgia (PHN) is the main sequelae. Until now, no index has been available to predict the pathogenesis of PHN, and rare reports have focused on the immune response during aging and PHN. In this study, we selected immunoglobulin and complement proteins as markers for humoral immunity, while T lymphocyte subsets and natural killer (NK) cells were selected as markers for cell immunity, to systematically study the characteristics of immune responses in the peripheral blood of HZ patients. Our data showed that the absolute number of CD3(+) T cells and CD8(+) T cells decreased during aging and PHN. This implies that more attention should be paid to prevent the occurrence of PHN, especially in the aged population.
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spelling pubmed-56781442017-11-17 Decreased absolute numbers of CD3(+) T cells and CD8(+) T cells during aging in herpes zoster patients Wei, Li Zhao, Jianguang Wu, Wei Zhang, Yu Fu, Xuyan Chen, Lifeng Wang, Xiaoting Sci Rep Article Herpes zoster (HZ) is an infectious dermatosis with high incidence worldwide. Age is a key risk factor for HZ, and postherpetic neuralgia (PHN) is the main sequelae. Until now, no index has been available to predict the pathogenesis of PHN, and rare reports have focused on the immune response during aging and PHN. In this study, we selected immunoglobulin and complement proteins as markers for humoral immunity, while T lymphocyte subsets and natural killer (NK) cells were selected as markers for cell immunity, to systematically study the characteristics of immune responses in the peripheral blood of HZ patients. Our data showed that the absolute number of CD3(+) T cells and CD8(+) T cells decreased during aging and PHN. This implies that more attention should be paid to prevent the occurrence of PHN, especially in the aged population. Nature Publishing Group UK 2017-11-08 /pmc/articles/PMC5678144/ /pubmed/29118328 http://dx.doi.org/10.1038/s41598-017-15390-w Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Wei, Li
Zhao, Jianguang
Wu, Wei
Zhang, Yu
Fu, Xuyan
Chen, Lifeng
Wang, Xiaoting
Decreased absolute numbers of CD3(+) T cells and CD8(+) T cells during aging in herpes zoster patients
title Decreased absolute numbers of CD3(+) T cells and CD8(+) T cells during aging in herpes zoster patients
title_full Decreased absolute numbers of CD3(+) T cells and CD8(+) T cells during aging in herpes zoster patients
title_fullStr Decreased absolute numbers of CD3(+) T cells and CD8(+) T cells during aging in herpes zoster patients
title_full_unstemmed Decreased absolute numbers of CD3(+) T cells and CD8(+) T cells during aging in herpes zoster patients
title_short Decreased absolute numbers of CD3(+) T cells and CD8(+) T cells during aging in herpes zoster patients
title_sort decreased absolute numbers of cd3(+) t cells and cd8(+) t cells during aging in herpes zoster patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678144/
https://www.ncbi.nlm.nih.gov/pubmed/29118328
http://dx.doi.org/10.1038/s41598-017-15390-w
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