WNT10A variants isolated from Japanese patients with congenital tooth agenesis

It has been reported that dozens of WNT10A variants are associated with human isolated tooth agenesis, however, little is known about the precise phenotypes. In 50 Japanese patients with severe congenital tooth agenesis, we identified 11 patients with WNT10A variants. Comparing phenotypes between th...

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Autores principales: Machida, Junichiro, Goto, Hiroaki, Tatematsu, Tadashi, Shibata, Akio, Miyachi, Hitoshi, Takahashi, Katsu, Izumi, Hiroto, Nakayama, Atsuo, Shimozato, Kazuo, Tokita, Yoshihito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Data Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678204/
https://www.ncbi.nlm.nih.gov/pubmed/29367877
http://dx.doi.org/10.1038/hgv.2017.47
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author Machida, Junichiro
Goto, Hiroaki
Tatematsu, Tadashi
Shibata, Akio
Miyachi, Hitoshi
Takahashi, Katsu
Izumi, Hiroto
Nakayama, Atsuo
Shimozato, Kazuo
Tokita, Yoshihito
author_facet Machida, Junichiro
Goto, Hiroaki
Tatematsu, Tadashi
Shibata, Akio
Miyachi, Hitoshi
Takahashi, Katsu
Izumi, Hiroto
Nakayama, Atsuo
Shimozato, Kazuo
Tokita, Yoshihito
author_sort Machida, Junichiro
collection PubMed
description It has been reported that dozens of WNT10A variants are associated with human isolated tooth agenesis, however, little is known about the precise phenotypes. In 50 Japanese patients with severe congenital tooth agenesis, we identified 11 patients with WNT10A variants. Comparing phenotypes between the tooth agenesis patients carrying the wild-type and variants of WNT10A, we revealed that the development of lateral incisors is relatively susceptive to insufficiency of WNT/β-catenin signaling.
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spelling pubmed-56782042018-01-24 WNT10A variants isolated from Japanese patients with congenital tooth agenesis Machida, Junichiro Goto, Hiroaki Tatematsu, Tadashi Shibata, Akio Miyachi, Hitoshi Takahashi, Katsu Izumi, Hiroto Nakayama, Atsuo Shimozato, Kazuo Tokita, Yoshihito Hum Genome Var Data Report It has been reported that dozens of WNT10A variants are associated with human isolated tooth agenesis, however, little is known about the precise phenotypes. In 50 Japanese patients with severe congenital tooth agenesis, we identified 11 patients with WNT10A variants. Comparing phenotypes between the tooth agenesis patients carrying the wild-type and variants of WNT10A, we revealed that the development of lateral incisors is relatively susceptive to insufficiency of WNT/β-catenin signaling. Nature Publishing Group 2017-11-09 /pmc/articles/PMC5678204/ /pubmed/29367877 http://dx.doi.org/10.1038/hgv.2017.47 Text en Copyright © 2017 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/
spellingShingle Data Report
Machida, Junichiro
Goto, Hiroaki
Tatematsu, Tadashi
Shibata, Akio
Miyachi, Hitoshi
Takahashi, Katsu
Izumi, Hiroto
Nakayama, Atsuo
Shimozato, Kazuo
Tokita, Yoshihito
WNT10A variants isolated from Japanese patients with congenital tooth agenesis
title WNT10A variants isolated from Japanese patients with congenital tooth agenesis
title_full WNT10A variants isolated from Japanese patients with congenital tooth agenesis
title_fullStr WNT10A variants isolated from Japanese patients with congenital tooth agenesis
title_full_unstemmed WNT10A variants isolated from Japanese patients with congenital tooth agenesis
title_short WNT10A variants isolated from Japanese patients with congenital tooth agenesis
title_sort wnt10a variants isolated from japanese patients with congenital tooth agenesis
topic Data Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678204/
https://www.ncbi.nlm.nih.gov/pubmed/29367877
http://dx.doi.org/10.1038/hgv.2017.47
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