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PTEN Regulates PI(3,4)P(2) Signaling Downstream of Class I PI3K

The PI3K signaling pathway regulates cell growth and movement and is heavily mutated in cancer. Class I PI3Ks synthesize the lipid messenger PI(3,4,5)P(3). PI(3,4,5)P(3) can be dephosphorylated by 3- or 5-phosphatases, the latter producing PI(3,4)P(2). The PTEN tumor suppressor is thought to functio...

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Detalles Bibliográficos
Autores principales:	Malek, Mouhannad, Kielkowska, Anna, Chessa, Tamara, Anderson, Karen E., Barneda, David, Pir, Pınar, Nakanishi, Hiroki, Eguchi, Satoshi, Koizumi, Atsushi, Sasaki, Junko, Juvin, Véronique, Kiselev, Vladimir Y., Niewczas, Izabella, Gray, Alexander, Valayer, Alexandre, Spensberger, Dominik, Imbert, Marine, Felisbino, Sergio, Habuchi, Tomonori, Beinke, Soren, Cosulich, Sabina, Le Novère, Nicolas, Sasaki, Takehiko, Clark, Jonathan, Hawkins, Phillip T., Stephens, Len R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678281/ https://www.ncbi.nlm.nih.gov/pubmed/29056325 http://dx.doi.org/10.1016/j.molcel.2017.09.024

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