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The role of succinate and ROS in reperfusion injury – A critical appraisal

We critically assess the proposal that succinate-fuelled reverse electron flow (REF) drives mitochondrial matrix superoxide production from Complex I early in reperfusion, thus acting as a key mediator of ischemia/reperfusion (IR) injury. Real-time surface fluorescence measurements of NAD(P)H and fl...

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Detalles Bibliográficos
Autores principales:	Andrienko, Tatyana N., Pasdois, Philippe, Pereira, Gonçalo C., Ovens, Matthew J., Halestrap, Andrew P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Academic Press 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678286/ https://www.ncbi.nlm.nih.gov/pubmed/28689004 http://dx.doi.org/10.1016/j.yjmcc.2017.06.016

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