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Investigations into within- and between-subject resting-state amplitude variations
The amplitudes of spontaneous fluctuations in brain activity may be a significant source of within-subject and between-subject variability, and this variability is likely to be carried through into functional connectivity (FC) estimates (whether directly or indirectly). Therefore, improving our unde...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Academic Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678294/ https://www.ncbi.nlm.nih.gov/pubmed/28712995 http://dx.doi.org/10.1016/j.neuroimage.2017.07.014 |
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author | Bijsterbosch, Janine Harrison, Samuel Duff, Eugene Alfaro-Almagro, Fidel Woolrich, Mark Smith, Stephen |
author_facet | Bijsterbosch, Janine Harrison, Samuel Duff, Eugene Alfaro-Almagro, Fidel Woolrich, Mark Smith, Stephen |
author_sort | Bijsterbosch, Janine |
collection | PubMed |
description | The amplitudes of spontaneous fluctuations in brain activity may be a significant source of within-subject and between-subject variability, and this variability is likely to be carried through into functional connectivity (FC) estimates (whether directly or indirectly). Therefore, improving our understanding of amplitude fluctuations over the course of a resting state scan and variation in amplitude across individuals is of great relevance to the interpretation of FC findings. We investigate resting state amplitudes in two large-scale studies (HCP and UK Biobank), with the aim of determining between-subject and within-subject variability. Between-subject clustering distinguished between two groups of brain networks whose amplitude variation across subjects were highly correlated with each other, revealing a clear distinction between primary sensory and motor regions (‘primary sensory/motor cluster’) and cognitive networks. Within subjects, all networks in the primary sensory/motor cluster showed a consistent increase in amplitudes from the start to the end of the scan. In addition to the strong increases in primary sensory/motor amplitude, a large number of changes in FC were found when comparing the two scans acquired on the same day (HCP data). Additive signal change analysis confirmed that all of the observed FC changes could be fully explained by changes in amplitude. Between-subject correlations in UK Biobank data showed a negative correlation between primary sensory/motor amplitude and average sleep duration, suggesting a role of arousal. Our findings additionally reveal complex relationships between amplitude and head motion. These results suggest that network amplitude is a source of significant variability both across subjects, and within subjects on a within-session timescale. Future rfMRI studies may benefit from obtaining arousal-related (self report) measures, and may wish to consider the influence of amplitude changes on measures of (dynamic) functional connectivity. |
format | Online Article Text |
id | pubmed-5678294 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Academic Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-56782942017-11-20 Investigations into within- and between-subject resting-state amplitude variations Bijsterbosch, Janine Harrison, Samuel Duff, Eugene Alfaro-Almagro, Fidel Woolrich, Mark Smith, Stephen Neuroimage Article The amplitudes of spontaneous fluctuations in brain activity may be a significant source of within-subject and between-subject variability, and this variability is likely to be carried through into functional connectivity (FC) estimates (whether directly or indirectly). Therefore, improving our understanding of amplitude fluctuations over the course of a resting state scan and variation in amplitude across individuals is of great relevance to the interpretation of FC findings. We investigate resting state amplitudes in two large-scale studies (HCP and UK Biobank), with the aim of determining between-subject and within-subject variability. Between-subject clustering distinguished between two groups of brain networks whose amplitude variation across subjects were highly correlated with each other, revealing a clear distinction between primary sensory and motor regions (‘primary sensory/motor cluster’) and cognitive networks. Within subjects, all networks in the primary sensory/motor cluster showed a consistent increase in amplitudes from the start to the end of the scan. In addition to the strong increases in primary sensory/motor amplitude, a large number of changes in FC were found when comparing the two scans acquired on the same day (HCP data). Additive signal change analysis confirmed that all of the observed FC changes could be fully explained by changes in amplitude. Between-subject correlations in UK Biobank data showed a negative correlation between primary sensory/motor amplitude and average sleep duration, suggesting a role of arousal. Our findings additionally reveal complex relationships between amplitude and head motion. These results suggest that network amplitude is a source of significant variability both across subjects, and within subjects on a within-session timescale. Future rfMRI studies may benefit from obtaining arousal-related (self report) measures, and may wish to consider the influence of amplitude changes on measures of (dynamic) functional connectivity. Academic Press 2017-10-01 /pmc/articles/PMC5678294/ /pubmed/28712995 http://dx.doi.org/10.1016/j.neuroimage.2017.07.014 Text en © 2017 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Bijsterbosch, Janine Harrison, Samuel Duff, Eugene Alfaro-Almagro, Fidel Woolrich, Mark Smith, Stephen Investigations into within- and between-subject resting-state amplitude variations |
title | Investigations into within- and between-subject resting-state amplitude variations |
title_full | Investigations into within- and between-subject resting-state amplitude variations |
title_fullStr | Investigations into within- and between-subject resting-state amplitude variations |
title_full_unstemmed | Investigations into within- and between-subject resting-state amplitude variations |
title_short | Investigations into within- and between-subject resting-state amplitude variations |
title_sort | investigations into within- and between-subject resting-state amplitude variations |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678294/ https://www.ncbi.nlm.nih.gov/pubmed/28712995 http://dx.doi.org/10.1016/j.neuroimage.2017.07.014 |
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