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Rickettsial retinitis: Direct bacterial infection or an immune-mediated response?
Infectious retinitis postfebrile illness is known to be caused by chikungunya, dengue, West Nile virus, Bartonella, Lyme's disease, Rift Valley fever, rickettsia, Herpes viruses etc. Rickettsia is Gram-negative bacteria transmitted by arthropods vectors. Ocular involvement is common including c...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Medknow Publications & Media Pvt Ltd
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678310/ https://www.ncbi.nlm.nih.gov/pubmed/29044082 http://dx.doi.org/10.4103/ijo.IJO_369_17 |
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author | Chawla, Rohan Pundlik, Gadkar Amit Chaudhry, Rama Thakur, Chandan |
author_facet | Chawla, Rohan Pundlik, Gadkar Amit Chaudhry, Rama Thakur, Chandan |
author_sort | Chawla, Rohan |
collection | PubMed |
description | Infectious retinitis postfebrile illness is known to be caused by chikungunya, dengue, West Nile virus, Bartonella, Lyme's disease, Rift Valley fever, rickettsia, Herpes viruses etc. Rickettsia is Gram-negative bacteria transmitted by arthropods vectors. Ocular involvement is common including conjunctivitis, keratitis, anterior uveitis, panuveitis, retinitis, retinal vascular changes, and optic nerve involvement. Retinitis lesions in rickettsia can occur because of an immunological response to the bacteria or because of direct invasion and proliferation of bacteria in the inner retina. We report such a case of bilateral rickettsial retinitis proven by serology which worsened on systemic steroids and responded dramatically to therapy with oral doxycycline and steroid taper. We thus believe that direct bacterial invasion plays a major role in the pathogenesis of rickettsial retinitis. |
format | Online Article Text |
id | pubmed-5678310 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-56783102017-11-28 Rickettsial retinitis: Direct bacterial infection or an immune-mediated response? Chawla, Rohan Pundlik, Gadkar Amit Chaudhry, Rama Thakur, Chandan Indian J Ophthalmol Brief Communications Infectious retinitis postfebrile illness is known to be caused by chikungunya, dengue, West Nile virus, Bartonella, Lyme's disease, Rift Valley fever, rickettsia, Herpes viruses etc. Rickettsia is Gram-negative bacteria transmitted by arthropods vectors. Ocular involvement is common including conjunctivitis, keratitis, anterior uveitis, panuveitis, retinitis, retinal vascular changes, and optic nerve involvement. Retinitis lesions in rickettsia can occur because of an immunological response to the bacteria or because of direct invasion and proliferation of bacteria in the inner retina. We report such a case of bilateral rickettsial retinitis proven by serology which worsened on systemic steroids and responded dramatically to therapy with oral doxycycline and steroid taper. We thus believe that direct bacterial invasion plays a major role in the pathogenesis of rickettsial retinitis. Medknow Publications & Media Pvt Ltd 2017-10 /pmc/articles/PMC5678310/ /pubmed/29044082 http://dx.doi.org/10.4103/ijo.IJO_369_17 Text en Copyright: © 2017 Indian Journal of Ophthalmology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Brief Communications Chawla, Rohan Pundlik, Gadkar Amit Chaudhry, Rama Thakur, Chandan Rickettsial retinitis: Direct bacterial infection or an immune-mediated response? |
title | Rickettsial retinitis: Direct bacterial infection or an immune-mediated response? |
title_full | Rickettsial retinitis: Direct bacterial infection or an immune-mediated response? |
title_fullStr | Rickettsial retinitis: Direct bacterial infection or an immune-mediated response? |
title_full_unstemmed | Rickettsial retinitis: Direct bacterial infection or an immune-mediated response? |
title_short | Rickettsial retinitis: Direct bacterial infection or an immune-mediated response? |
title_sort | rickettsial retinitis: direct bacterial infection or an immune-mediated response? |
topic | Brief Communications |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678310/ https://www.ncbi.nlm.nih.gov/pubmed/29044082 http://dx.doi.org/10.4103/ijo.IJO_369_17 |
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