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Rickettsial retinitis: Direct bacterial infection or an immune-mediated response?

Infectious retinitis postfebrile illness is known to be caused by chikungunya, dengue, West Nile virus, Bartonella, Lyme's disease, Rift Valley fever, rickettsia, Herpes viruses etc. Rickettsia is Gram-negative bacteria transmitted by arthropods vectors. Ocular involvement is common including c...

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Detalles Bibliográficos
Autores principales: Chawla, Rohan, Pundlik, Gadkar Amit, Chaudhry, Rama, Thakur, Chandan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678310/
https://www.ncbi.nlm.nih.gov/pubmed/29044082
http://dx.doi.org/10.4103/ijo.IJO_369_17
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author Chawla, Rohan
Pundlik, Gadkar Amit
Chaudhry, Rama
Thakur, Chandan
author_facet Chawla, Rohan
Pundlik, Gadkar Amit
Chaudhry, Rama
Thakur, Chandan
author_sort Chawla, Rohan
collection PubMed
description Infectious retinitis postfebrile illness is known to be caused by chikungunya, dengue, West Nile virus, Bartonella, Lyme's disease, Rift Valley fever, rickettsia, Herpes viruses etc. Rickettsia is Gram-negative bacteria transmitted by arthropods vectors. Ocular involvement is common including conjunctivitis, keratitis, anterior uveitis, panuveitis, retinitis, retinal vascular changes, and optic nerve involvement. Retinitis lesions in rickettsia can occur because of an immunological response to the bacteria or because of direct invasion and proliferation of bacteria in the inner retina. We report such a case of bilateral rickettsial retinitis proven by serology which worsened on systemic steroids and responded dramatically to therapy with oral doxycycline and steroid taper. We thus believe that direct bacterial invasion plays a major role in the pathogenesis of rickettsial retinitis.
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spelling pubmed-56783102017-11-28 Rickettsial retinitis: Direct bacterial infection or an immune-mediated response? Chawla, Rohan Pundlik, Gadkar Amit Chaudhry, Rama Thakur, Chandan Indian J Ophthalmol Brief Communications Infectious retinitis postfebrile illness is known to be caused by chikungunya, dengue, West Nile virus, Bartonella, Lyme's disease, Rift Valley fever, rickettsia, Herpes viruses etc. Rickettsia is Gram-negative bacteria transmitted by arthropods vectors. Ocular involvement is common including conjunctivitis, keratitis, anterior uveitis, panuveitis, retinitis, retinal vascular changes, and optic nerve involvement. Retinitis lesions in rickettsia can occur because of an immunological response to the bacteria or because of direct invasion and proliferation of bacteria in the inner retina. We report such a case of bilateral rickettsial retinitis proven by serology which worsened on systemic steroids and responded dramatically to therapy with oral doxycycline and steroid taper. We thus believe that direct bacterial invasion plays a major role in the pathogenesis of rickettsial retinitis. Medknow Publications & Media Pvt Ltd 2017-10 /pmc/articles/PMC5678310/ /pubmed/29044082 http://dx.doi.org/10.4103/ijo.IJO_369_17 Text en Copyright: © 2017 Indian Journal of Ophthalmology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Brief Communications
Chawla, Rohan
Pundlik, Gadkar Amit
Chaudhry, Rama
Thakur, Chandan
Rickettsial retinitis: Direct bacterial infection or an immune-mediated response?
title Rickettsial retinitis: Direct bacterial infection or an immune-mediated response?
title_full Rickettsial retinitis: Direct bacterial infection or an immune-mediated response?
title_fullStr Rickettsial retinitis: Direct bacterial infection or an immune-mediated response?
title_full_unstemmed Rickettsial retinitis: Direct bacterial infection or an immune-mediated response?
title_short Rickettsial retinitis: Direct bacterial infection or an immune-mediated response?
title_sort rickettsial retinitis: direct bacterial infection or an immune-mediated response?
topic Brief Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678310/
https://www.ncbi.nlm.nih.gov/pubmed/29044082
http://dx.doi.org/10.4103/ijo.IJO_369_17
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