An endosiRNA-Based Repression Mechanism Counteracts Transposon Activation during Global DNA Demethylation in Embryonic Stem Cells

Erasure of DNA methylation and repressive chromatin marks in the mammalian germline leads to risk of transcriptional activation of transposable elements (TEs). Here, we used mouse embryonic stem cells (ESCs) to identify an endosiRNA-based mechanism involved in suppression of TE transcription. In ESC...

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Detalles Bibliográficos
Autores principales: Berrens, Rebecca V., Andrews, Simon, Spensberger, Dominik, Santos, Fátima, Dean, Wendy, Gould, Poppy, Sharif, Jafar, Olova, Nelly, Chandra, Tamir, Koseki, Haruhiko, von Meyenn, Ferdinand, Reik, Wolf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678422/
https://www.ncbi.nlm.nih.gov/pubmed/29100015
http://dx.doi.org/10.1016/j.stem.2017.10.004

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