A new antagonist for CCR4 attenuates allergic lung inflammation in a mouse model of asthma

CCR4 is highly expressed on Th2 cells. CCR4 ligands include CCL22 and CCL17. Chemokine-like factor 1 can also mediate chemotaxis via CCR4. We designed and synthetized novel CCR4 antagonists, which were piperazinyl pyridine derivatives, for disrupting the interaction between three ligands and CCR4. W...

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Detalles Bibliográficos
Autores principales: Zhang, Yang, Wu, Yinfang, Qi, Hui, Xiao, Junhai, Gong, Hongwei, Zhang, Yan, Xu, Enquan, Li, Song, Ma, Dalong, Wang, Ying, Li, Wen, Shen, Huahao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678437/
https://www.ncbi.nlm.nih.gov/pubmed/29118379
http://dx.doi.org/10.1038/s41598-017-11868-9

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