High resolution IgH repertoire analysis reveals fetal liver as the likely origin of life-long, innate B lymphopoiesis in humans

The ontogeny of the natural, public IgM repertoire remains incompletely explored. Here, high-resolution immunogenetic analysis of B cells from (unrelated) fetal, child, and adult samples, shows that although fetal liver (FL) and bone marrow (FBM) IgM repertoires are equally diversified, FL is the ma...

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Detalles Bibliográficos
Autores principales: Roy, Anindita, Bystry, Vojtech, Bohn, Georg, Goudevenou, Katerina, Reigl, Tomas, Papaioannou, Maria, Krejci, Adam, O'Byrne, Sorcha, Chaidos, Aristeidis, Grioni, Andrea, Darzentas, Nikos, Roberts, Irene A.G., Karadimitris, Anastasios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678457/
https://www.ncbi.nlm.nih.gov/pubmed/28645875
http://dx.doi.org/10.1016/j.clim.2017.06.005

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