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Tissue-specific role of RHBDF2 in cutaneous wound healing and hyperproliferative skin disease

OBJECTIVE: Gain-of-function (GOF) mutations in RHBDF2 cause tylosis. Patients present with hyperproliferative skin, and keratinocytes from tylosis patients’ skin show an enhanced wound-healing phenotype. The curly bare mouse model of tylosis, carrying a GOF mutation in the Rhbdf2 gene (Rhbdf2 (cub))...

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Detalles Bibliográficos
Autores principales:	Hosur, Vishnu, Lyons, Bonnie L., Burzenski, Lisa M., Shultz, Leonard D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research Note
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678570/ https://www.ncbi.nlm.nih.gov/pubmed/29116018 http://dx.doi.org/10.1186/s13104-017-2899-8

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