Co-targeting PI3K, mTOR, and IGF1R with small molecule inhibitors for treating undifferentiated pleomorphic sarcoma

Undifferentiated pleomorphic sarcomas (UPSs) are aggressive mesenchymal malignancies with no definitive cell of origin or specific recurrent genetic hallmarks. These tumors are largely chemoresistant; thus, identification of potential therapeutic targets is necessary to improve patient outcome. Prev...

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Detalles Bibliográficos
Autores principales: May, Caitlin D., Landers, Sharon M., Bolshakov, Svetlana, Ma, XiaoYan, Ingram, Davis R., Kivlin, Christine M., Watson, Kelsey L., Sannaa, Ghadah A. Al, Bhalla, Angela D., Wang, Wei-Lien, Lazar, Alexander J., Torres, Keila E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678691/
https://www.ncbi.nlm.nih.gov/pubmed/29099264
http://dx.doi.org/10.1080/15384047.2017.1373230

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