Sensitivity analysis revealing the effect of modulating ionic mechanisms on calcium dynamics in simulated human heart failure

Abnormal intracellular Ca(2+) handling is the major contributor to the depressed cardiac contractility observed in heart failure. The electrophysiological remodeling associated with this pathology alters both the action potential and the Ca(2+) dynamics, leading to a defective excitation-contraction...

Descripción completa

Detalles Bibliográficos
Autores principales: Mora, Maria T., Ferrero, Jose M., Romero, Lucia, Trenor, Beatriz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678731/
https://www.ncbi.nlm.nih.gov/pubmed/29117223
http://dx.doi.org/10.1371/journal.pone.0187739

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678731/
https://www.ncbi.nlm.nih.gov/pubmed/29117223
http://dx.doi.org/10.1371/journal.pone.0187739

Ejemplares similares