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Sensitivity analysis revealing the effect of modulating ionic mechanisms on calcium dynamics in simulated human heart failure
Abnormal intracellular Ca(2+) handling is the major contributor to the depressed cardiac contractility observed in heart failure. The electrophysiological remodeling associated with this pathology alters both the action potential and the Ca(2+) dynamics, leading to a defective excitation-contraction...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678731/ https://www.ncbi.nlm.nih.gov/pubmed/29117223 http://dx.doi.org/10.1371/journal.pone.0187739 |