Depletion of somatic mutations in splicing-associated sequences in cancer genomes

BACKGROUND: An important goal of cancer genomics is to identify systematically cancer-causing mutations. A common approach is to identify sites with high ratios of non-synonymous to synonymous mutations; however, if synonymous mutations are under purifying selection, this methodology leads to identi...

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Detalles Bibliográficos
Autores principales: Hurst, Laurence D., Batada, Nizar N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678748/
https://www.ncbi.nlm.nih.gov/pubmed/29115978
http://dx.doi.org/10.1186/s13059-017-1337-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678748/
https://www.ncbi.nlm.nih.gov/pubmed/29115978
http://dx.doi.org/10.1186/s13059-017-1337-5

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