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Depletion of somatic mutations in splicing-associated sequences in cancer genomes

BACKGROUND: An important goal of cancer genomics is to identify systematically cancer-causing mutations. A common approach is to identify sites with high ratios of non-synonymous to synonymous mutations; however, if synonymous mutations are under purifying selection, this methodology leads to identi...

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Detalles Bibliográficos
Autores principales:	Hurst, Laurence D., Batada, Nizar N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678748/ https://www.ncbi.nlm.nih.gov/pubmed/29115978 http://dx.doi.org/10.1186/s13059-017-1337-5

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