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Low Urinary Creatinine Excretion Is Associated With Self-Reported Frailty in Patients With Advanced Chronic Kidney Disease

INTRODUCTION: Frailty and muscle wasting, a component of frailty, are common in advanced stage chronic kidney disease (CKD). Whether frailty is associated with low urinary creatinine excretion (UCrE) as a measure of muscle mass in this population is unknown. Furthermore, reference values of UCrE are...

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Autores principales: Polinder-Bos, Harmke A., Nacak, Hakan, Dekker, Friedo W., Bakker, Stephan J.L., Gaillard, Carlo A.J.M., Gansevoort, Ron T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678832/
https://www.ncbi.nlm.nih.gov/pubmed/29142985
http://dx.doi.org/10.1016/j.ekir.2017.02.021
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author Polinder-Bos, Harmke A.
Nacak, Hakan
Dekker, Friedo W.
Bakker, Stephan J.L.
Gaillard, Carlo A.J.M.
Gansevoort, Ron T.
author_facet Polinder-Bos, Harmke A.
Nacak, Hakan
Dekker, Friedo W.
Bakker, Stephan J.L.
Gaillard, Carlo A.J.M.
Gansevoort, Ron T.
author_sort Polinder-Bos, Harmke A.
collection PubMed
description INTRODUCTION: Frailty and muscle wasting, a component of frailty, are common in advanced stage chronic kidney disease (CKD). Whether frailty is associated with low urinary creatinine excretion (UCrE) as a measure of muscle mass in this population is unknown. Furthermore, reference values of UCrE are lacking. We first defined low UCrE and studied correlates of low UCrE, and subsequently studied cross-sectional associations of frailty with low UCrE in patients with advanced CKD. METHODS: A total of 2748 healthy individuals of the general population-based PREVEND study were included to define low UCrE (UCrE indexed for height, below the age- and sex-specific 5th percentile of the distribution). Frailty was defined using a modification of the Fried frailty phenotype. In a CKD population that included 320 and 967 participants of the PREPARE-2 and NECOSAD studies, respectively, cross-sectional associations of self-reported frailty, the individual components that define self-reported frailty, and frailty-associated variables with low UCrE were evaluated using multivariate logistic and linear regression models. RESULTS: Low UCrE was found in 38% of the CKD patients. A lower glomerular filtration rate was strongly associated with low UCrE. Self-reported frailty (adjusted odds ratio: 2.19; 95% confidence interval: 1.28−3.77) and the individual components were associated with low UCrE, independent of comorbidities. The frailty-associated variables hemoglobin and albumin were inversely associated with low UCrE, and parathyroid hormone was positively associated with low UCrE. DISCUSSION: Lower kidney function is a strong correlate of low UCrE and self-reported frailty, and the individual frailty components are associated with low UCrE as well, independent of comorbidities.
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spelling pubmed-56788322017-11-15 Low Urinary Creatinine Excretion Is Associated With Self-Reported Frailty in Patients With Advanced Chronic Kidney Disease Polinder-Bos, Harmke A. Nacak, Hakan Dekker, Friedo W. Bakker, Stephan J.L. Gaillard, Carlo A.J.M. Gansevoort, Ron T. Kidney Int Rep Clinical Research INTRODUCTION: Frailty and muscle wasting, a component of frailty, are common in advanced stage chronic kidney disease (CKD). Whether frailty is associated with low urinary creatinine excretion (UCrE) as a measure of muscle mass in this population is unknown. Furthermore, reference values of UCrE are lacking. We first defined low UCrE and studied correlates of low UCrE, and subsequently studied cross-sectional associations of frailty with low UCrE in patients with advanced CKD. METHODS: A total of 2748 healthy individuals of the general population-based PREVEND study were included to define low UCrE (UCrE indexed for height, below the age- and sex-specific 5th percentile of the distribution). Frailty was defined using a modification of the Fried frailty phenotype. In a CKD population that included 320 and 967 participants of the PREPARE-2 and NECOSAD studies, respectively, cross-sectional associations of self-reported frailty, the individual components that define self-reported frailty, and frailty-associated variables with low UCrE were evaluated using multivariate logistic and linear regression models. RESULTS: Low UCrE was found in 38% of the CKD patients. A lower glomerular filtration rate was strongly associated with low UCrE. Self-reported frailty (adjusted odds ratio: 2.19; 95% confidence interval: 1.28−3.77) and the individual components were associated with low UCrE, independent of comorbidities. The frailty-associated variables hemoglobin and albumin were inversely associated with low UCrE, and parathyroid hormone was positively associated with low UCrE. DISCUSSION: Lower kidney function is a strong correlate of low UCrE and self-reported frailty, and the individual frailty components are associated with low UCrE as well, independent of comorbidities. Elsevier 2017-03-10 /pmc/articles/PMC5678832/ /pubmed/29142985 http://dx.doi.org/10.1016/j.ekir.2017.02.021 Text en © 2017 International Society of Nephrology. Published by Elsevier Inc. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Clinical Research
Polinder-Bos, Harmke A.
Nacak, Hakan
Dekker, Friedo W.
Bakker, Stephan J.L.
Gaillard, Carlo A.J.M.
Gansevoort, Ron T.
Low Urinary Creatinine Excretion Is Associated With Self-Reported Frailty in Patients With Advanced Chronic Kidney Disease
title Low Urinary Creatinine Excretion Is Associated With Self-Reported Frailty in Patients With Advanced Chronic Kidney Disease
title_full Low Urinary Creatinine Excretion Is Associated With Self-Reported Frailty in Patients With Advanced Chronic Kidney Disease
title_fullStr Low Urinary Creatinine Excretion Is Associated With Self-Reported Frailty in Patients With Advanced Chronic Kidney Disease
title_full_unstemmed Low Urinary Creatinine Excretion Is Associated With Self-Reported Frailty in Patients With Advanced Chronic Kidney Disease
title_short Low Urinary Creatinine Excretion Is Associated With Self-Reported Frailty in Patients With Advanced Chronic Kidney Disease
title_sort low urinary creatinine excretion is associated with self-reported frailty in patients with advanced chronic kidney disease
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678832/
https://www.ncbi.nlm.nih.gov/pubmed/29142985
http://dx.doi.org/10.1016/j.ekir.2017.02.021
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