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Glomerulopathy Associated With Moderate Obesity
INTRODUCTION: Obesity-related glomerulopathy is an established secondary glomerular disease that may occur in obese individuals with a body mass index (BMI) of ≥30 kg/m(2). However, patients with moderate obesity (BMI ≤ 30 kg/m(2)) may also develop this disease. METHODS: A total of 20 patients with...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678835/ https://www.ncbi.nlm.nih.gov/pubmed/29142929 http://dx.doi.org/10.1016/j.ekir.2016.08.006 |
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author | Okabayashi, Yusuke Tsuboi, Nobuo Sasaki, Takaya Haruhara, Kotaro Kanzaki, Go Koike, Kentaro Miyazaki, Yoichi Kawamura, Tetsuya Ogura, Makoto Yokoo, Takashi |
author_facet | Okabayashi, Yusuke Tsuboi, Nobuo Sasaki, Takaya Haruhara, Kotaro Kanzaki, Go Koike, Kentaro Miyazaki, Yoichi Kawamura, Tetsuya Ogura, Makoto Yokoo, Takashi |
author_sort | Okabayashi, Yusuke |
collection | PubMed |
description | INTRODUCTION: Obesity-related glomerulopathy is an established secondary glomerular disease that may occur in obese individuals with a body mass index (BMI) of ≥30 kg/m(2). However, patients with moderate obesity (BMI ≤ 30 kg/m(2)) may also develop this disease. METHODS: A total of 20 patients with grade 1 obesity (25 ≤ BMI < 30 kg/m(2)) with persistent proteinuria, without evidence of other renal diseases, were analyzed retrospectively. These patients were compared with 20 patients with grade 2 or higher obesity (BMI ≥ 30 kg/m(2)) with persistent proteinuria. Biopsies of 31 kidney transplant donors as healthy controls were used to compare histologic parameters. RESULTS: Similar to the grade 2 or higher obesity group, the grade 1 obesity group had a male predominance (85%) and showed a high incidence of hypertension (80%). Urinary protein excretion and renal outcome parameters were comparable between the groups. Patients with grade 1 obesity showed typical histologic features of obesity-related glomerulopathy: low glomerular density with glomerulomegaly. The glomerular density and mean glomerular volume in the grade 1 group, the grade 2 or higher group, and the kidney transplant donors with grade 1 obesity were 1.6 ± 0.8 versus 1.4 ± 0.6 versus 3.0 ± 1.1 (per mm(2)) and 6.1 ± 2.1 versus 6.4 ± 1.6 versus 2.9 ± 0.8 (×10(6) μm(3)), respectively. DISCUSSION: A glomerulopathy similar to obesity-related glomerulopathy can occur in moderately obese individuals. Renal factor(s), such as low glomerular density, may thus underlie susceptibility to this disease entity as well as BMI. |
format | Online Article Text |
id | pubmed-5678835 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-56788352017-11-15 Glomerulopathy Associated With Moderate Obesity Okabayashi, Yusuke Tsuboi, Nobuo Sasaki, Takaya Haruhara, Kotaro Kanzaki, Go Koike, Kentaro Miyazaki, Yoichi Kawamura, Tetsuya Ogura, Makoto Yokoo, Takashi Kidney Int Rep Clinical Research INTRODUCTION: Obesity-related glomerulopathy is an established secondary glomerular disease that may occur in obese individuals with a body mass index (BMI) of ≥30 kg/m(2). However, patients with moderate obesity (BMI ≤ 30 kg/m(2)) may also develop this disease. METHODS: A total of 20 patients with grade 1 obesity (25 ≤ BMI < 30 kg/m(2)) with persistent proteinuria, without evidence of other renal diseases, were analyzed retrospectively. These patients were compared with 20 patients with grade 2 or higher obesity (BMI ≥ 30 kg/m(2)) with persistent proteinuria. Biopsies of 31 kidney transplant donors as healthy controls were used to compare histologic parameters. RESULTS: Similar to the grade 2 or higher obesity group, the grade 1 obesity group had a male predominance (85%) and showed a high incidence of hypertension (80%). Urinary protein excretion and renal outcome parameters were comparable between the groups. Patients with grade 1 obesity showed typical histologic features of obesity-related glomerulopathy: low glomerular density with glomerulomegaly. The glomerular density and mean glomerular volume in the grade 1 group, the grade 2 or higher group, and the kidney transplant donors with grade 1 obesity were 1.6 ± 0.8 versus 1.4 ± 0.6 versus 3.0 ± 1.1 (per mm(2)) and 6.1 ± 2.1 versus 6.4 ± 1.6 versus 2.9 ± 0.8 (×10(6) μm(3)), respectively. DISCUSSION: A glomerulopathy similar to obesity-related glomerulopathy can occur in moderately obese individuals. Renal factor(s), such as low glomerular density, may thus underlie susceptibility to this disease entity as well as BMI. Elsevier 2016-08-12 /pmc/articles/PMC5678835/ /pubmed/29142929 http://dx.doi.org/10.1016/j.ekir.2016.08.006 Text en © 2016 International Society of Nephrology. Published by Elsevier Inc. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Clinical Research Okabayashi, Yusuke Tsuboi, Nobuo Sasaki, Takaya Haruhara, Kotaro Kanzaki, Go Koike, Kentaro Miyazaki, Yoichi Kawamura, Tetsuya Ogura, Makoto Yokoo, Takashi Glomerulopathy Associated With Moderate Obesity |
title | Glomerulopathy Associated With Moderate Obesity |
title_full | Glomerulopathy Associated With Moderate Obesity |
title_fullStr | Glomerulopathy Associated With Moderate Obesity |
title_full_unstemmed | Glomerulopathy Associated With Moderate Obesity |
title_short | Glomerulopathy Associated With Moderate Obesity |
title_sort | glomerulopathy associated with moderate obesity |
topic | Clinical Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678835/ https://www.ncbi.nlm.nih.gov/pubmed/29142929 http://dx.doi.org/10.1016/j.ekir.2016.08.006 |
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