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Glomerulopathy Associated With Moderate Obesity

INTRODUCTION: Obesity-related glomerulopathy is an established secondary glomerular disease that may occur in obese individuals with a body mass index (BMI) of ≥30 kg/m(2). However, patients with moderate obesity (BMI ≤ 30 kg/m(2)) may also develop this disease. METHODS: A total of 20 patients with...

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Autores principales: Okabayashi, Yusuke, Tsuboi, Nobuo, Sasaki, Takaya, Haruhara, Kotaro, Kanzaki, Go, Koike, Kentaro, Miyazaki, Yoichi, Kawamura, Tetsuya, Ogura, Makoto, Yokoo, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678835/
https://www.ncbi.nlm.nih.gov/pubmed/29142929
http://dx.doi.org/10.1016/j.ekir.2016.08.006
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author Okabayashi, Yusuke
Tsuboi, Nobuo
Sasaki, Takaya
Haruhara, Kotaro
Kanzaki, Go
Koike, Kentaro
Miyazaki, Yoichi
Kawamura, Tetsuya
Ogura, Makoto
Yokoo, Takashi
author_facet Okabayashi, Yusuke
Tsuboi, Nobuo
Sasaki, Takaya
Haruhara, Kotaro
Kanzaki, Go
Koike, Kentaro
Miyazaki, Yoichi
Kawamura, Tetsuya
Ogura, Makoto
Yokoo, Takashi
author_sort Okabayashi, Yusuke
collection PubMed
description INTRODUCTION: Obesity-related glomerulopathy is an established secondary glomerular disease that may occur in obese individuals with a body mass index (BMI) of ≥30 kg/m(2). However, patients with moderate obesity (BMI ≤ 30 kg/m(2)) may also develop this disease. METHODS: A total of 20 patients with grade 1 obesity (25 ≤ BMI < 30 kg/m(2)) with persistent proteinuria, without evidence of other renal diseases, were analyzed retrospectively. These patients were compared with 20 patients with grade 2 or higher obesity (BMI ≥ 30 kg/m(2)) with persistent proteinuria. Biopsies of 31 kidney transplant donors as healthy controls were used to compare histologic parameters. RESULTS: Similar to the grade 2 or higher obesity group, the grade 1 obesity group had a male predominance (85%) and showed a high incidence of hypertension (80%). Urinary protein excretion and renal outcome parameters were comparable between the groups. Patients with grade 1 obesity showed typical histologic features of obesity-related glomerulopathy: low glomerular density with glomerulomegaly. The glomerular density and mean glomerular volume in the grade 1 group, the grade 2 or higher group, and the kidney transplant donors with grade 1 obesity were 1.6 ± 0.8 versus 1.4 ± 0.6 versus 3.0 ± 1.1 (per mm(2)) and 6.1 ± 2.1 versus 6.4 ± 1.6 versus 2.9 ± 0.8 (×10(6) μm(3)), respectively. DISCUSSION: A glomerulopathy similar to obesity-related glomerulopathy can occur in moderately obese individuals. Renal factor(s), such as low glomerular density, may thus underlie susceptibility to this disease entity as well as BMI.
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spelling pubmed-56788352017-11-15 Glomerulopathy Associated With Moderate Obesity Okabayashi, Yusuke Tsuboi, Nobuo Sasaki, Takaya Haruhara, Kotaro Kanzaki, Go Koike, Kentaro Miyazaki, Yoichi Kawamura, Tetsuya Ogura, Makoto Yokoo, Takashi Kidney Int Rep Clinical Research INTRODUCTION: Obesity-related glomerulopathy is an established secondary glomerular disease that may occur in obese individuals with a body mass index (BMI) of ≥30 kg/m(2). However, patients with moderate obesity (BMI ≤ 30 kg/m(2)) may also develop this disease. METHODS: A total of 20 patients with grade 1 obesity (25 ≤ BMI < 30 kg/m(2)) with persistent proteinuria, without evidence of other renal diseases, were analyzed retrospectively. These patients were compared with 20 patients with grade 2 or higher obesity (BMI ≥ 30 kg/m(2)) with persistent proteinuria. Biopsies of 31 kidney transplant donors as healthy controls were used to compare histologic parameters. RESULTS: Similar to the grade 2 or higher obesity group, the grade 1 obesity group had a male predominance (85%) and showed a high incidence of hypertension (80%). Urinary protein excretion and renal outcome parameters were comparable between the groups. Patients with grade 1 obesity showed typical histologic features of obesity-related glomerulopathy: low glomerular density with glomerulomegaly. The glomerular density and mean glomerular volume in the grade 1 group, the grade 2 or higher group, and the kidney transplant donors with grade 1 obesity were 1.6 ± 0.8 versus 1.4 ± 0.6 versus 3.0 ± 1.1 (per mm(2)) and 6.1 ± 2.1 versus 6.4 ± 1.6 versus 2.9 ± 0.8 (×10(6) μm(3)), respectively. DISCUSSION: A glomerulopathy similar to obesity-related glomerulopathy can occur in moderately obese individuals. Renal factor(s), such as low glomerular density, may thus underlie susceptibility to this disease entity as well as BMI. Elsevier 2016-08-12 /pmc/articles/PMC5678835/ /pubmed/29142929 http://dx.doi.org/10.1016/j.ekir.2016.08.006 Text en © 2016 International Society of Nephrology. Published by Elsevier Inc. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Clinical Research
Okabayashi, Yusuke
Tsuboi, Nobuo
Sasaki, Takaya
Haruhara, Kotaro
Kanzaki, Go
Koike, Kentaro
Miyazaki, Yoichi
Kawamura, Tetsuya
Ogura, Makoto
Yokoo, Takashi
Glomerulopathy Associated With Moderate Obesity
title Glomerulopathy Associated With Moderate Obesity
title_full Glomerulopathy Associated With Moderate Obesity
title_fullStr Glomerulopathy Associated With Moderate Obesity
title_full_unstemmed Glomerulopathy Associated With Moderate Obesity
title_short Glomerulopathy Associated With Moderate Obesity
title_sort glomerulopathy associated with moderate obesity
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678835/
https://www.ncbi.nlm.nih.gov/pubmed/29142929
http://dx.doi.org/10.1016/j.ekir.2016.08.006
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