HCFC2 is needed for IRF1- and IRF2-dependent Tlr3 transcription and for survival during viral infections

Transcriptional regulation of numerous interferon-regulated genes, including Toll-like receptor 3 (Tlr3), which encodes an innate immune sensor of viral double-stranded RNA, depends on the interferon regulatory factor 1 (IRF1) and IRF2 transcription factors. We detected specific abrogation of macrop...

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Detalles Bibliográficos
Autores principales: Sun, Lei, Jiang, Zhengfan, Acosta-Rodriguez, Victoria A., Berger, Michael, Du, Xin, Choi, Jin Huk, Wang, Jianhui, Wang, Kuan-wen, Kilaru, Gokhul K., Mohawk, Jennifer A., Quan, Jiexia, Scott, Lindsay, Hildebrand, Sara, Li, Xiaohong, Tang, Miao, Zhan, Xiaoming, Murray, Anne R., La Vine, Diantha, Moresco, Eva Marie Y., Takahashi, Joseph S., Beutler, Bruce
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679162/
https://www.ncbi.nlm.nih.gov/pubmed/28970238
http://dx.doi.org/10.1084/jem.20161630

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