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Thrombospondin1 (TSP1) replacement prevents cerebral cavernous malformations

KRIT1 mutations are the most common cause of cerebral cavernous malformation (CCM). Acute Krit1 gene inactivation in mouse brain microvascular endothelial cells (BMECs) changes expression of multiple genes involved in vascular development. These changes include suppression of Thbs1, which encodes th...

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Detalles Bibliográficos
Autores principales:	Lopez-Ramirez, Miguel Alejandro, Fonseca, Gregory, Zeineddine, Hussein A., Girard, Romuald, Moore, Thomas, Pham, Angela, Cao, Ying, Shenkar, Robert, de Kreuk, Bart-Jan, Lagarrigue, Frederic, Lawler, Jack, Glass, Christopher K., Awad, Issam A., Ginsberg, Mark H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2017
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679163/ https://www.ncbi.nlm.nih.gov/pubmed/28970240 http://dx.doi.org/10.1084/jem.20171178

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