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ICAMs support B cell interactions with T follicular helper cells and promote clonal selection

The germinal center (GC) reaction begins with a diverse and expanded group of B cell clones bearing a wide range of antibody affinities. During GC colonization, B cells engage in long-lasting interactions with T follicular helper (Tfh) cells, a process that depends on antigen uptake and antigen pres...

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Autores principales: Zaretsky, Irina, Atrakchi, Ofir, Mazor, Roei D., Stoler-Barak, Liat, Biram, Adi, Feigelson, Sara W., Gitlin, Alexander D., Engelhardt, Britta, Shulman, Ziv
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679169/
https://www.ncbi.nlm.nih.gov/pubmed/28939548
http://dx.doi.org/10.1084/jem.20171129
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author Zaretsky, Irina
Atrakchi, Ofir
Mazor, Roei D.
Stoler-Barak, Liat
Biram, Adi
Feigelson, Sara W.
Gitlin, Alexander D.
Engelhardt, Britta
Shulman, Ziv
author_facet Zaretsky, Irina
Atrakchi, Ofir
Mazor, Roei D.
Stoler-Barak, Liat
Biram, Adi
Feigelson, Sara W.
Gitlin, Alexander D.
Engelhardt, Britta
Shulman, Ziv
author_sort Zaretsky, Irina
collection PubMed
description The germinal center (GC) reaction begins with a diverse and expanded group of B cell clones bearing a wide range of antibody affinities. During GC colonization, B cells engage in long-lasting interactions with T follicular helper (Tfh) cells, a process that depends on antigen uptake and antigen presentation to the Tfh cells. How long-lasting T–B interactions and B cell clonal expansion are regulated by antigen presentation remains unclear. Here, we use in vivo B cell competition models and intravital imaging to examine the adhesive mechanisms governing B cell selection for GC colonization. We find that intercellular adhesion molecule 1 (ICAM-1) and ICAM-2 on B cells are essential for long-lasting cognate Tfh–B cell interactions and efficient selection of low-affinity B cell clones for proliferative clonal expansion. Thus, B cell ICAMs promote efficient antibody immune response by enhancement of T cell help to cognate B cells.
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spelling pubmed-56791692018-05-06 ICAMs support B cell interactions with T follicular helper cells and promote clonal selection Zaretsky, Irina Atrakchi, Ofir Mazor, Roei D. Stoler-Barak, Liat Biram, Adi Feigelson, Sara W. Gitlin, Alexander D. Engelhardt, Britta Shulman, Ziv J Exp Med Research Articles The germinal center (GC) reaction begins with a diverse and expanded group of B cell clones bearing a wide range of antibody affinities. During GC colonization, B cells engage in long-lasting interactions with T follicular helper (Tfh) cells, a process that depends on antigen uptake and antigen presentation to the Tfh cells. How long-lasting T–B interactions and B cell clonal expansion are regulated by antigen presentation remains unclear. Here, we use in vivo B cell competition models and intravital imaging to examine the adhesive mechanisms governing B cell selection for GC colonization. We find that intercellular adhesion molecule 1 (ICAM-1) and ICAM-2 on B cells are essential for long-lasting cognate Tfh–B cell interactions and efficient selection of low-affinity B cell clones for proliferative clonal expansion. Thus, B cell ICAMs promote efficient antibody immune response by enhancement of T cell help to cognate B cells. The Rockefeller University Press 2017-11-06 /pmc/articles/PMC5679169/ /pubmed/28939548 http://dx.doi.org/10.1084/jem.20171129 Text en © 2017 Zaretsky et al. http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Research Articles
Zaretsky, Irina
Atrakchi, Ofir
Mazor, Roei D.
Stoler-Barak, Liat
Biram, Adi
Feigelson, Sara W.
Gitlin, Alexander D.
Engelhardt, Britta
Shulman, Ziv
ICAMs support B cell interactions with T follicular helper cells and promote clonal selection
title ICAMs support B cell interactions with T follicular helper cells and promote clonal selection
title_full ICAMs support B cell interactions with T follicular helper cells and promote clonal selection
title_fullStr ICAMs support B cell interactions with T follicular helper cells and promote clonal selection
title_full_unstemmed ICAMs support B cell interactions with T follicular helper cells and promote clonal selection
title_short ICAMs support B cell interactions with T follicular helper cells and promote clonal selection
title_sort icams support b cell interactions with t follicular helper cells and promote clonal selection
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679169/
https://www.ncbi.nlm.nih.gov/pubmed/28939548
http://dx.doi.org/10.1084/jem.20171129
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