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PTEN drives Th17 cell differentiation by preventing IL-2 production

T helper 17 (Th17) cells are a CD4(+) T cell subset that produces IL-17A to mediate inflammation and autoimmunity. IL-2 inhibits Th17 cell differentiation. However, the mechanism by which IL-2 is suppressed during Th17 cell differentiation remains unclear. Here, we show that phosphatase and tensin h...

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Detalles Bibliográficos
Autores principales:	Kim, Hyeong Su, Jang, Sung Woong, Lee, Wonyong, Kim, Kiwan, Sohn, Hyogon, Hwang, Soo Seok, Lee, Gap Ryol
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2017
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679178/ https://www.ncbi.nlm.nih.gov/pubmed/29018045 http://dx.doi.org/10.1084/jem.20170523

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