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Ablation of epidermal RXRα in cooperation with activated CDK4 and oncogenic NRAS generates spontaneous and acute neonatal UVB induced malignant metastatic melanomas
BACKGROUND: Understanding the underlying molecular mechanisms involved in the formation of cutaneous malignant melanoma is critical for improved diagnosis and treatment. Keratinocytic nuclear receptor Retinoid X Receptor α (RXRα) has a protective role against melanomagenesis and is involved in the r...
Autores principales: | Chagani, Sharmeen, Wang, Rong, Carpenter, Evan L., Löhr, Christiane V., Ganguli-Indra, Gitali, Indra, Arup K. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679438/ https://www.ncbi.nlm.nih.gov/pubmed/29121869 http://dx.doi.org/10.1186/s12885-017-3714-6 |
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