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Loss of function JAK1 mutations occur at high frequency in cancers with microsatellite instability and are suggestive of immune evasion

Immune evasion is a well-recognized hallmark of cancer and recent studies with immunotherapy agents have suggested that tumors with increased numbers of neoantigens elicit greater immune responses. We hypothesized that the immune system presents a common selective pressure on high mutation burden tu...

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Detalles Bibliográficos
Autores principales:	Albacker, Lee A., Wu, Jeremy, Smith, Peter, Warmuth, Markus, Stephens, Philip J., Zhu, Ping, Yu, Lihua, Chmielecki, Juliann
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679612/ https://www.ncbi.nlm.nih.gov/pubmed/29121062 http://dx.doi.org/10.1371/journal.pone.0176181

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