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Associations between fatty liver index and asymptomatic intracranial vertebrobasilar stenosis in Chinese population

Metabolic diseases such as type 2 diabetes mellitus (T2DM) and metabolic syndromes (MetS) have been recognized as the important risk factors for asymptomatic intracranial vertebrobasilar stenosis (IVBS). Although fatty liver index (FLI) is significantly related with these diseases, the association b...

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Autores principales: Qiu, Jing, Zhou, Zhiwei, Wang, Jie, Wang, Yiying, Liu, Chunxing, Liu, Xingxiang, Xu, Yunfang, Yu, Lugang, Zhou, Hui, Lin, Jie, Guo, Zhirong, Dong, Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679613/
https://www.ncbi.nlm.nih.gov/pubmed/29121660
http://dx.doi.org/10.1371/journal.pone.0187502
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author Qiu, Jing
Zhou, Zhiwei
Wang, Jie
Wang, Yiying
Liu, Chunxing
Liu, Xingxiang
Xu, Yunfang
Yu, Lugang
Zhou, Hui
Lin, Jie
Guo, Zhirong
Dong, Chen
author_facet Qiu, Jing
Zhou, Zhiwei
Wang, Jie
Wang, Yiying
Liu, Chunxing
Liu, Xingxiang
Xu, Yunfang
Yu, Lugang
Zhou, Hui
Lin, Jie
Guo, Zhirong
Dong, Chen
author_sort Qiu, Jing
collection PubMed
description Metabolic diseases such as type 2 diabetes mellitus (T2DM) and metabolic syndromes (MetS) have been recognized as the important risk factors for asymptomatic intracranial vertebrobasilar stenosis (IVBS). Although fatty liver index (FLI) is significantly related with these diseases, the association between FLI and IVBS remains unclear. In the present study, 2368 participants (30–75 years) were recruited from a Chinese prospective cohort study of PMMJS. Amongst them, 2281 individuals who did not have IVBS at baseline were enrolled in the 6-year following-up study. In cross-sectional analysis based on the baseline characteristics, the results showed that FLI was positively related with IVBS prevalence. Compared to the participants with FLI < 30, the adjusted OR (95% CI) of IVBS was 2.07 (1.18, 3.62) and 2.85 (1.39, 5.18) in the groups of 30 ≤ FLI < 60 and FLI ≥ 60, respectively. In longitudinal analysis, the results showed that the participants with FLI ≥ 60 had an increased risk of asymptomatic IVBS compared to those with FLI < 30 [adjusted HR (95%CI): 1.65 (1.05, 2.60)]. Moreover, exclusion of persons with hypertension, T2DM and MetS did not alter the associations between FLI and asymptomatic IVBS. Therefore, our results suggest that elevated FLI is an independent risk factor for asymptomatic IVBS in Chinese adults.
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spelling pubmed-56796132017-11-18 Associations between fatty liver index and asymptomatic intracranial vertebrobasilar stenosis in Chinese population Qiu, Jing Zhou, Zhiwei Wang, Jie Wang, Yiying Liu, Chunxing Liu, Xingxiang Xu, Yunfang Yu, Lugang Zhou, Hui Lin, Jie Guo, Zhirong Dong, Chen PLoS One Research Article Metabolic diseases such as type 2 diabetes mellitus (T2DM) and metabolic syndromes (MetS) have been recognized as the important risk factors for asymptomatic intracranial vertebrobasilar stenosis (IVBS). Although fatty liver index (FLI) is significantly related with these diseases, the association between FLI and IVBS remains unclear. In the present study, 2368 participants (30–75 years) were recruited from a Chinese prospective cohort study of PMMJS. Amongst them, 2281 individuals who did not have IVBS at baseline were enrolled in the 6-year following-up study. In cross-sectional analysis based on the baseline characteristics, the results showed that FLI was positively related with IVBS prevalence. Compared to the participants with FLI < 30, the adjusted OR (95% CI) of IVBS was 2.07 (1.18, 3.62) and 2.85 (1.39, 5.18) in the groups of 30 ≤ FLI < 60 and FLI ≥ 60, respectively. In longitudinal analysis, the results showed that the participants with FLI ≥ 60 had an increased risk of asymptomatic IVBS compared to those with FLI < 30 [adjusted HR (95%CI): 1.65 (1.05, 2.60)]. Moreover, exclusion of persons with hypertension, T2DM and MetS did not alter the associations between FLI and asymptomatic IVBS. Therefore, our results suggest that elevated FLI is an independent risk factor for asymptomatic IVBS in Chinese adults. Public Library of Science 2017-11-09 /pmc/articles/PMC5679613/ /pubmed/29121660 http://dx.doi.org/10.1371/journal.pone.0187502 Text en © 2017 Qiu et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Qiu, Jing
Zhou, Zhiwei
Wang, Jie
Wang, Yiying
Liu, Chunxing
Liu, Xingxiang
Xu, Yunfang
Yu, Lugang
Zhou, Hui
Lin, Jie
Guo, Zhirong
Dong, Chen
Associations between fatty liver index and asymptomatic intracranial vertebrobasilar stenosis in Chinese population
title Associations between fatty liver index and asymptomatic intracranial vertebrobasilar stenosis in Chinese population
title_full Associations between fatty liver index and asymptomatic intracranial vertebrobasilar stenosis in Chinese population
title_fullStr Associations between fatty liver index and asymptomatic intracranial vertebrobasilar stenosis in Chinese population
title_full_unstemmed Associations between fatty liver index and asymptomatic intracranial vertebrobasilar stenosis in Chinese population
title_short Associations between fatty liver index and asymptomatic intracranial vertebrobasilar stenosis in Chinese population
title_sort associations between fatty liver index and asymptomatic intracranial vertebrobasilar stenosis in chinese population
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679613/
https://www.ncbi.nlm.nih.gov/pubmed/29121660
http://dx.doi.org/10.1371/journal.pone.0187502
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