PFI1785w: A highly conserved protein associated with pregnancy associated malaria

Pregnancy-associated malaria (PAM) is one of the severe forms of Plasmodium falciparum infection. The main antigen VAR2CSA is the target of vaccine development. However, the large size of VAR2CSA protein and its high degree of variability limit to the efficiency of the vaccination. Using quantitativ...

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Autores principales: Kamaliddin, Claire, Salnot, Virginie, Leduc, Marjorie, Ezinmegnon, Sem, Broussard, Cédric, Fievet, Nadine, Deloron, Philippe, Guillonneau, François, Bertin, Gwladys I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679621/
https://www.ncbi.nlm.nih.gov/pubmed/29121643
http://dx.doi.org/10.1371/journal.pone.0187817
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author Kamaliddin, Claire
Salnot, Virginie
Leduc, Marjorie
Ezinmegnon, Sem
Broussard, Cédric
Fievet, Nadine
Deloron, Philippe
Guillonneau, François
Bertin, Gwladys I.
author_facet Kamaliddin, Claire
Salnot, Virginie
Leduc, Marjorie
Ezinmegnon, Sem
Broussard, Cédric
Fievet, Nadine
Deloron, Philippe
Guillonneau, François
Bertin, Gwladys I.
author_sort Kamaliddin, Claire
collection PubMed
description Pregnancy-associated malaria (PAM) is one of the severe forms of Plasmodium falciparum infection. The main antigen VAR2CSA is the target of vaccine development. However, the large size of VAR2CSA protein and its high degree of variability limit to the efficiency of the vaccination. Using quantitative mass spectrometry method, we detected and quantified proteotypic peptides from 5 predicted PAM associated proteins. Our results confirmed that PFI1785w is over-expressed in PAM samples. Then, we investigated PFI1785w variability among a set of parasite samples from various endemic areas. PFI1785w appear to be more conserved than VAR2CSA. PFB0115w, another PAM associated protein, seems also associated with the pathology. Further vaccination strategies could integrate other proteins in addition to the major VAR2CSA antigen to improve immune response to vaccination.
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spelling pubmed-56796212017-11-18 PFI1785w: A highly conserved protein associated with pregnancy associated malaria Kamaliddin, Claire Salnot, Virginie Leduc, Marjorie Ezinmegnon, Sem Broussard, Cédric Fievet, Nadine Deloron, Philippe Guillonneau, François Bertin, Gwladys I. PLoS One Research Article Pregnancy-associated malaria (PAM) is one of the severe forms of Plasmodium falciparum infection. The main antigen VAR2CSA is the target of vaccine development. However, the large size of VAR2CSA protein and its high degree of variability limit to the efficiency of the vaccination. Using quantitative mass spectrometry method, we detected and quantified proteotypic peptides from 5 predicted PAM associated proteins. Our results confirmed that PFI1785w is over-expressed in PAM samples. Then, we investigated PFI1785w variability among a set of parasite samples from various endemic areas. PFI1785w appear to be more conserved than VAR2CSA. PFB0115w, another PAM associated protein, seems also associated with the pathology. Further vaccination strategies could integrate other proteins in addition to the major VAR2CSA antigen to improve immune response to vaccination. Public Library of Science 2017-11-09 /pmc/articles/PMC5679621/ /pubmed/29121643 http://dx.doi.org/10.1371/journal.pone.0187817 Text en © 2017 Kamaliddin et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Kamaliddin, Claire
Salnot, Virginie
Leduc, Marjorie
Ezinmegnon, Sem
Broussard, Cédric
Fievet, Nadine
Deloron, Philippe
Guillonneau, François
Bertin, Gwladys I.
PFI1785w: A highly conserved protein associated with pregnancy associated malaria
title PFI1785w: A highly conserved protein associated with pregnancy associated malaria
title_full PFI1785w: A highly conserved protein associated with pregnancy associated malaria
title_fullStr PFI1785w: A highly conserved protein associated with pregnancy associated malaria
title_full_unstemmed PFI1785w: A highly conserved protein associated with pregnancy associated malaria
title_short PFI1785w: A highly conserved protein associated with pregnancy associated malaria
title_sort pfi1785w: a highly conserved protein associated with pregnancy associated malaria
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679621/
https://www.ncbi.nlm.nih.gov/pubmed/29121643
http://dx.doi.org/10.1371/journal.pone.0187817
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