miRNA independent hepacivirus variants suggest a strong evolutionary pressure to maintain miR-122 dependence

Hepatitis C virus (HCV) requires the liver specific micro-RNA (miRNA), miR-122, to replicate. This was considered unique among RNA viruses until recent discoveries of HCV-related hepaciviruses prompting the question of a more general miR-122 dependence. Among hepaciviruses, the closest known HCV rel...

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Detalles Bibliográficos
Autores principales: Yu, Yingpu, Scheel, Troels K. H., Luna, Joseph M., Chung, Hachung, Nishiuchi, Eiko, Scull, Margaret A., Echeverría, Natalia, Ricardo-Lax, Inna, Kapoor, Amit, Lipkin, Ian W., Divers, Thomas J., Antczak, Douglas F., Tennant, Bud C., Rice, Charles M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679655/
https://www.ncbi.nlm.nih.gov/pubmed/29084265
http://dx.doi.org/10.1371/journal.ppat.1006694

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