Cargando…

Association of GEMIN4 gene polymorphism and the risk of cancer: a meta-analysis

Gem-associated protein 4 (GEMIN4) gene is a key regulator for the miRNA biogenesis processes. Recent studies have demonstrated that some single-nucleotide polymorphisms (SNPs) in GEMIN4 gene are associated with the risk of cancer, but the results are still controversial. Therefore, we conducted a me...

Descripción completa

Detalles Bibliográficos
Autores principales: Wu, Nan, Zhang, Xiaowei, Tian, Jinlong, Yu, Shuang, Qiao, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679687/
https://www.ncbi.nlm.nih.gov/pubmed/29138579
http://dx.doi.org/10.2147/OTT.S147204
_version_ 1783277632138248192
author Wu, Nan
Zhang, Xiaowei
Tian, Jinlong
Yu, Shuang
Qiao, Ying
author_facet Wu, Nan
Zhang, Xiaowei
Tian, Jinlong
Yu, Shuang
Qiao, Ying
author_sort Wu, Nan
collection PubMed
description Gem-associated protein 4 (GEMIN4) gene is a key regulator for the miRNA biogenesis processes. Recent studies have demonstrated that some single-nucleotide polymorphisms (SNPs) in GEMIN4 gene are associated with the risk of cancer, but the results are still controversial. Therefore, we conducted a meta-analysis to analyze the association between three major SNPs (rs2740348, rs7813, and rs3744741) in the GEMIN4 gene and the risk of cancer. Relevant articles were searched in Web of Science, PubMed, Cochrane Library, Chinese Wan Fang, and Chinese National Knowledge Infrastructure databases. Pooled odds ratio (OR) with 95% confidence interval (CI) was calculated to quantitatively estimate the association. Publication bias and sensitivity analyses were undertaken to evaluate the stability of the results. Overall, the pooled results showed that rs2740348 involving 3,604 cases and 3,770 controls was significantly associated with increased cancer risk (GG vs GC/CC: OR =1.16, 95% CI =1.05–1.29, P=0.004) and rs7813 involving 4,729 cases and 4,562 controls was also related to increased cancer risk (TT vs TC/CC: OR =1.12, 95% CI =1.03–1.22, P=0.009). However, there was no significant association between rs3744741 and cancer risk under overall genetic models. In conclusion, our study has demonstrated that rs2740348 and rs7813 are associated with increased risk of cancer, and they may be new biomarkers for predicting cancer risk.
format Online
Article
Text
id pubmed-5679687
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Dove Medical Press
record_format MEDLINE/PubMed
spelling pubmed-56796872017-11-14 Association of GEMIN4 gene polymorphism and the risk of cancer: a meta-analysis Wu, Nan Zhang, Xiaowei Tian, Jinlong Yu, Shuang Qiao, Ying Onco Targets Ther Original Research Gem-associated protein 4 (GEMIN4) gene is a key regulator for the miRNA biogenesis processes. Recent studies have demonstrated that some single-nucleotide polymorphisms (SNPs) in GEMIN4 gene are associated with the risk of cancer, but the results are still controversial. Therefore, we conducted a meta-analysis to analyze the association between three major SNPs (rs2740348, rs7813, and rs3744741) in the GEMIN4 gene and the risk of cancer. Relevant articles were searched in Web of Science, PubMed, Cochrane Library, Chinese Wan Fang, and Chinese National Knowledge Infrastructure databases. Pooled odds ratio (OR) with 95% confidence interval (CI) was calculated to quantitatively estimate the association. Publication bias and sensitivity analyses were undertaken to evaluate the stability of the results. Overall, the pooled results showed that rs2740348 involving 3,604 cases and 3,770 controls was significantly associated with increased cancer risk (GG vs GC/CC: OR =1.16, 95% CI =1.05–1.29, P=0.004) and rs7813 involving 4,729 cases and 4,562 controls was also related to increased cancer risk (TT vs TC/CC: OR =1.12, 95% CI =1.03–1.22, P=0.009). However, there was no significant association between rs3744741 and cancer risk under overall genetic models. In conclusion, our study has demonstrated that rs2740348 and rs7813 are associated with increased risk of cancer, and they may be new biomarkers for predicting cancer risk. Dove Medical Press 2017-11-02 /pmc/articles/PMC5679687/ /pubmed/29138579 http://dx.doi.org/10.2147/OTT.S147204 Text en © 2017 Wu et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Wu, Nan
Zhang, Xiaowei
Tian, Jinlong
Yu, Shuang
Qiao, Ying
Association of GEMIN4 gene polymorphism and the risk of cancer: a meta-analysis
title Association of GEMIN4 gene polymorphism and the risk of cancer: a meta-analysis
title_full Association of GEMIN4 gene polymorphism and the risk of cancer: a meta-analysis
title_fullStr Association of GEMIN4 gene polymorphism and the risk of cancer: a meta-analysis
title_full_unstemmed Association of GEMIN4 gene polymorphism and the risk of cancer: a meta-analysis
title_short Association of GEMIN4 gene polymorphism and the risk of cancer: a meta-analysis
title_sort association of gemin4 gene polymorphism and the risk of cancer: a meta-analysis
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679687/
https://www.ncbi.nlm.nih.gov/pubmed/29138579
http://dx.doi.org/10.2147/OTT.S147204
work_keys_str_mv AT wunan associationofgemin4genepolymorphismandtheriskofcancerametaanalysis
AT zhangxiaowei associationofgemin4genepolymorphismandtheriskofcancerametaanalysis
AT tianjinlong associationofgemin4genepolymorphismandtheriskofcancerametaanalysis
AT yushuang associationofgemin4genepolymorphismandtheriskofcancerametaanalysis
AT qiaoying associationofgemin4genepolymorphismandtheriskofcancerametaanalysis