Targeting Glioma Stem Cells through Combined BMI1 and EZH2 Inhibition

Glioblastomas are lethal cancers defined by angiogenesis and pseudopalisading necrosis. Here, we demonstrate that these histological features are associated with distinct transcriptional programs, with vascular regions showing a proneural profile and hypoxic regions a mesenchymal pattern. As these r...

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Detalles Bibliográficos
Autores principales: Jin, Xun, Kim, Leo J. Y., Wu, Qiulian, Wallace, Lisa C., Prager, Briana C., Sanvoranart, Tanwarat, Gimple, Ryan C., Wang, Xiuxing, Mack, Stephen C., Miller, Tyler E., Huang, Ping, Valentim, Claudia L., Zhou, Qi-gang, Barnholtz-Sloan, Jill S., Bao, Shideng, Sloan, Andrew E., Rich, Jeremy N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679732/
https://www.ncbi.nlm.nih.gov/pubmed/29035367
http://dx.doi.org/10.1038/nm.4415

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679732/
https://www.ncbi.nlm.nih.gov/pubmed/29035367
http://dx.doi.org/10.1038/nm.4415

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