Cargando…

Targeting Glioma Stem Cells through Combined BMI1 and EZH2 Inhibition

Glioblastomas are lethal cancers defined by angiogenesis and pseudopalisading necrosis. Here, we demonstrate that these histological features are associated with distinct transcriptional programs, with vascular regions showing a proneural profile and hypoxic regions a mesenchymal pattern. As these r...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jin, Xun, Kim, Leo J. Y., Wu, Qiulian, Wallace, Lisa C., Prager, Briana C., Sanvoranart, Tanwarat, Gimple, Ryan C., Wang, Xiuxing, Mack, Stephen C., Miller, Tyler E., Huang, Ping, Valentim, Claudia L., Zhou, Qi-gang, Barnholtz-Sloan, Jill S., Bao, Shideng, Sloan, Andrew E., Rich, Jeremy N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679732/ https://www.ncbi.nlm.nih.gov/pubmed/29035367 http://dx.doi.org/10.1038/nm.4415

Ejemplares similares

FSMP-08. TARGETING PYRIMIDINE SYNTHESIS ACCENTUATES MOLECULAR THERAPY RESPONSE IN GLIOBLASTOMA STEM CELLS
por: Yang, Kailin, et al.
Publicado: (2021)

SATB2 drives glioblastoma growth by recruiting CBP to promote FOXM1 expression in glioma stem cells
por: Tao, Weiwei, et al.
Publicado: (2020)

Superenhancer activation of KLHDC8A drives glioma ciliation and hedgehog signaling
por: Lee, Derrick, et al.
Publicado: (2023)

Deubiquitinase USP13 maintains glioblastoma stem cells by antagonizing FBXL14-mediated Myc ubiquitination
por: Fang, Xiaoguang, et al.
Publicado: (2017)

Editorial: Epigenetic and metabolic regulation of primary and metastatic brain cancers
por: Gimple, Ryan C., et al.
Publicado: (2023)

Chromatin landscapes reveal developmentally encoded transcriptional states that define human glioblastoma
por: Mack, Stephen C., et al.
Publicado: (2019)

Dual Role of WISP1 in maintaining glioma stem cells and tumor-supportive macrophages in glioblastoma
por: Tao, Weiwei, et al.
Publicado: (2020)

ADAR1-mediated RNA editing links ganglioside catabolism to glioblastoma stem cell maintenance
por: Jiang, Li, et al.
Publicado: (2022)

Targeting EYA2 tyrosine phosphatase activity in glioblastoma stem cells induces mitotic catastrophe
por: Zhang, Guoxin, et al.
Publicado: (2021)

RAS: Striking at the Core of the Oncogenic Circuitry
por: Gimple, Ryan C., et al.
Publicado: (2019)

Osteoporosis: the current status of mesenchymal stem cell-based therapy
por: Phetfong, Jitrada, et al.
Publicado: (2016)

CDC20 maintains tumor initiating cells
por: Xie, Qi, et al.
Publicado: (2015)

Leveraging Allele-Specific Expression for Therapeutic Response Gene Discovery in Glioblastoma
por: Sen, Arko, et al.
Publicado: (2022)

Frontiers of Oncology: Biobanking Resources for the 21(st )Century
por: Barnholtz-Sloan, Jill, et al.
Publicado: (2011)

Novel approaches to the analysis of family data in genetic epidemiology
por: Morris, Nathan, et al.
Publicado: (2015)

Computational identification of multi-omic correlates of anticancer therapeutic response
por: Stetson, Lindsay C, et al.
Publicado: (2014)

Erratum: Computational identification of multi-omic correlates of anticancer therapeutic response
por: Stetson, Lindsay C, et al.
Publicado: (2015)

Sex Differences in Time to Treat and Outcomes for Gliomas
por: Stabellini, Nickolas, et al.
Publicado: (2021)

Glioma stem cells activate platelets by plasma-independent thrombin production to promote glioblastoma tumorigenesis
por: Sloan, Anthony R, et al.
Publicado: (2022)

Epidemiology of Brain and Other CNS Tumors
por: Ostrom, Quinn T., et al.
Publicado: (2021)

The polycomb group proteins, BMI-1 and EZH2, are tumour-associated antigens
por: Steele, J C, et al.
Publicado: (2006)

Replication of GWAS “Hits” by Race for Breast and Prostate Cancers in European Americans and African Americans
por: Barnholtz-Sloan, Jill S., et al.
Publicado: (2011)

A PTPmu Biomarker is Associated with Increased Survival in Gliomas
por: Johansen, Mette L., et al.
Publicado: (2019)

Bevacizumab for the treatment of non-small cell lung cancer patients with synchronous brain metastases
por: Ascha, Mustafa S., et al.
Publicado: (2019)

LncRNA INHEG promotes glioma stem cell maintenance and tumorigenicity through regulating rRNA 2’-O-methylation
por: Liu, Lihui, et al.
Publicado: (2023)

Splitting random forest (SRF) for determining compact sets of genes that distinguish between cancer subtypes
por: Guan, Xiaowei, et al.
Publicado: (2012)

Treatment and surgical factors associated with longer-term glioblastoma survival: a National Cancer Database study
por: Malay, Sindhoosha, et al.
Publicado: (2020)

An independently validated nomogram for isocitrate dehydrogenase-wild-type glioblastoma patient survival
por: Gittleman, Haley, et al.
Publicado: (2019)

A comparison of relative survival and cause‐specific survival methods to measure net survival in cancer populations
por: Makkar, Nupur, et al.
Publicado: (2018)

BSCI-06. FREQUENCY OF BRAIN METASTASIS FROM BREAST AND LUNG CANCER IN THE UNITED STATES -- A POPULATION-BASED ASSESSMENT
por: Ostrom, Quinn, et al.
Publicado: (2019)

Treatment Outcomes for Primary Hepatic Angiosarcoma: National Cancer Database Analysis 2004–2014
por: Mangla, Ankit, et al.
Publicado: (2022)

Critical Partnerships: How to Develop a Trans-Disciplinary Research Team
por: Waite, Kristin A., et al.
Publicado: (2023)

Sorting nexin 10 sustains PDGF receptor signaling in glioblastoma stem cells via endosomal protein sorting
por: Gimple, Ryan C., et al.
Publicado: (2023)

APOE and FABP2 Polymorphisms and History of Myocardial Infarction, Stroke, Diabetes, and Gallbladder Disease
por: Kato, Ikuko, et al.
Publicado: (2011)

Gene interaction enrichment and network analysis to identify dysregulated pathways and their interactions in complex diseases
por: Liu, Yu, et al.
Publicado: (2012)

Editorial: Sex Difference in Cancer Genomics and Its Impact on Therapy
por: Peng, Sen, et al.
Publicado: (2021)

Identification of Variants in Primary and Recurrent Glioblastoma Using a Cancer-Specific Gene Panel and Whole Exome Sequencing
por: Virk, Selene M., et al.
Publicado: (2015)

Gliomas display distinct sex-based differential methylation patterns based on molecular subtype
por: Johansen, Mette L, et al.
Publicado: (2020)

Deubiquitinase HAUSP Stabilizes REST and Promotes Maintenance of Neural Progenitor Cells
por: Huang, Zhi, et al.
Publicado: (2011)

Network Signatures of Survival in Glioblastoma Multiforme
por: Patel, Vishal N., et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_sbvmgmpkl6sgbt8j7bcj9s441j