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Structural insight into TPX2-stimulated microtubule assembly

During mitosis and meiosis, microtubule (MT) assembly is locally upregulated by the chromatin-dependent Ran-GTP pathway. One of its key targets is the MT-associated spindle assembly factor TPX2. The molecular mechanism of how TPX2 stimulates MT assembly remains unknown because structural information...

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Detalles Bibliográficos
Autores principales:	Zhang, Rui, Roostalu, Johanna, Surrey, Thomas, Nogales, Eva
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2017
Materias:	Biochemistry and Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679754/ https://www.ncbi.nlm.nih.gov/pubmed/29120325 http://dx.doi.org/10.7554/eLife.30959

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