CRAF gene fusions in pediatric low-grade gliomas define a distinct drug response based on dimerization profiles

Pediatric low-grade gliomas (PLGGs) are commonly associated with BRAF gene fusions that aberrantly activate the mitogen-activated protein kinase (MAPK) signaling pathway. This has led to PLGG clinical trials utilizing RAF- and MAPK pathway-targeted therapeutics. Whole-genome profiling of PLGGs has a...

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Detalles Bibliográficos
Autores principales: Jain, P, Fierst, T M, Han, H J, Smith, T E, Vakil, A, Storm, P B, Resnick, A C, Waanders, A J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680138/
https://www.ncbi.nlm.nih.gov/pubmed/28806393
http://dx.doi.org/10.1038/onc.2017.276

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