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Zinc is a critical regulator of placental morphogenesis and maternal hemodynamics during pregnancy in mice

Zinc is an essential micronutrient in pregnancy and zinc deficiency impairs fetal growth. We used a mouse model of moderate zinc deficiency to investigate the physiological mechanisms by which zinc is important to placental morphogenesis and the maternal blood pressure changes during pregnancy. A 26...

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Autores principales: Wilson, Rebecca L., Leemaqz, Shalem Y., Goh, Zona, McAninch, Dale, Jankovic-Karasoulos, Tanja, Leghi, Gabriela E., Phillips, Jessica A., Colafella, Katrina Mirabito, Tran, Cuong, O’Leary, Sean, Buckberry, Sam, Pederson, Stephen, Robertson, Sarah A., Bianco-Miotto, Tina, Roberts, Claire T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680205/
https://www.ncbi.nlm.nih.gov/pubmed/29123159
http://dx.doi.org/10.1038/s41598-017-15085-2
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author Wilson, Rebecca L.
Leemaqz, Shalem Y.
Goh, Zona
McAninch, Dale
Jankovic-Karasoulos, Tanja
Leghi, Gabriela E.
Phillips, Jessica A.
Colafella, Katrina Mirabito
Tran, Cuong
O’Leary, Sean
Buckberry, Sam
Pederson, Stephen
Robertson, Sarah A.
Bianco-Miotto, Tina
Roberts, Claire T.
author_facet Wilson, Rebecca L.
Leemaqz, Shalem Y.
Goh, Zona
McAninch, Dale
Jankovic-Karasoulos, Tanja
Leghi, Gabriela E.
Phillips, Jessica A.
Colafella, Katrina Mirabito
Tran, Cuong
O’Leary, Sean
Buckberry, Sam
Pederson, Stephen
Robertson, Sarah A.
Bianco-Miotto, Tina
Roberts, Claire T.
author_sort Wilson, Rebecca L.
collection PubMed
description Zinc is an essential micronutrient in pregnancy and zinc deficiency impairs fetal growth. We used a mouse model of moderate zinc deficiency to investigate the physiological mechanisms by which zinc is important to placental morphogenesis and the maternal blood pressure changes during pregnancy. A 26% reduction in circulating zinc (P = 0.005) was exhibited in mice fed a moderately zinc-deficient diet. Zinc deficiency in pregnancy resulted in an 8% reduction in both near term fetal and placental weights (both P < 0.0001) indicative of disrupted placental development and function. Detailed morphological analysis confirmed changes to the placental labyrinth microstructure. Continuous monitoring of maternal mean arterial pressure (MAP) revealed a late gestation decrease in the zinc-deficient dams. Differential expression of a number of regulatory genes within maternal kidneys supported observations on MAP changes in gestation. Increased MAP late in gestation is required to maintain perfusion of multiple placentas within rodent pregnancies. Decreased MAP within the zinc-deficient dams implies reduced blood flow and nutrient delivery to the placenta. These findings show that adequate zinc status is required for correct placental morphogenesis and appropriate maternal blood pressure adaptations to pregnancy. We conclude that insufficient maternal zinc intake from before and during pregnancy is likely to impact in utero programming of offspring growth and development largely through effects to the placenta and maternal cardiovascular system.
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spelling pubmed-56802052017-11-17 Zinc is a critical regulator of placental morphogenesis and maternal hemodynamics during pregnancy in mice Wilson, Rebecca L. Leemaqz, Shalem Y. Goh, Zona McAninch, Dale Jankovic-Karasoulos, Tanja Leghi, Gabriela E. Phillips, Jessica A. Colafella, Katrina Mirabito Tran, Cuong O’Leary, Sean Buckberry, Sam Pederson, Stephen Robertson, Sarah A. Bianco-Miotto, Tina Roberts, Claire T. Sci Rep Article Zinc is an essential micronutrient in pregnancy and zinc deficiency impairs fetal growth. We used a mouse model of moderate zinc deficiency to investigate the physiological mechanisms by which zinc is important to placental morphogenesis and the maternal blood pressure changes during pregnancy. A 26% reduction in circulating zinc (P = 0.005) was exhibited in mice fed a moderately zinc-deficient diet. Zinc deficiency in pregnancy resulted in an 8% reduction in both near term fetal and placental weights (both P < 0.0001) indicative of disrupted placental development and function. Detailed morphological analysis confirmed changes to the placental labyrinth microstructure. Continuous monitoring of maternal mean arterial pressure (MAP) revealed a late gestation decrease in the zinc-deficient dams. Differential expression of a number of regulatory genes within maternal kidneys supported observations on MAP changes in gestation. Increased MAP late in gestation is required to maintain perfusion of multiple placentas within rodent pregnancies. Decreased MAP within the zinc-deficient dams implies reduced blood flow and nutrient delivery to the placenta. These findings show that adequate zinc status is required for correct placental morphogenesis and appropriate maternal blood pressure adaptations to pregnancy. We conclude that insufficient maternal zinc intake from before and during pregnancy is likely to impact in utero programming of offspring growth and development largely through effects to the placenta and maternal cardiovascular system. Nature Publishing Group UK 2017-11-09 /pmc/articles/PMC5680205/ /pubmed/29123159 http://dx.doi.org/10.1038/s41598-017-15085-2 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Wilson, Rebecca L.
Leemaqz, Shalem Y.
Goh, Zona
McAninch, Dale
Jankovic-Karasoulos, Tanja
Leghi, Gabriela E.
Phillips, Jessica A.
Colafella, Katrina Mirabito
Tran, Cuong
O’Leary, Sean
Buckberry, Sam
Pederson, Stephen
Robertson, Sarah A.
Bianco-Miotto, Tina
Roberts, Claire T.
Zinc is a critical regulator of placental morphogenesis and maternal hemodynamics during pregnancy in mice
title Zinc is a critical regulator of placental morphogenesis and maternal hemodynamics during pregnancy in mice
title_full Zinc is a critical regulator of placental morphogenesis and maternal hemodynamics during pregnancy in mice
title_fullStr Zinc is a critical regulator of placental morphogenesis and maternal hemodynamics during pregnancy in mice
title_full_unstemmed Zinc is a critical regulator of placental morphogenesis and maternal hemodynamics during pregnancy in mice
title_short Zinc is a critical regulator of placental morphogenesis and maternal hemodynamics during pregnancy in mice
title_sort zinc is a critical regulator of placental morphogenesis and maternal hemodynamics during pregnancy in mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680205/
https://www.ncbi.nlm.nih.gov/pubmed/29123159
http://dx.doi.org/10.1038/s41598-017-15085-2
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