IL-6/IL-12 Cytokine Receptor Shuffling of Extra- and Intracellular Domains Reveals Canonical STAT Activation via Synthetic IL-35 and IL-39 Signaling

IL-35 and IL-39 are recently discovered shared members of the IL-6- and IL-12–type cytokine family with immune-suppressive capacity. IL-35 has been reported to induce the formation of four different receptor complexes: gp130:IL-12β2, gp130:gp130, IL-12β2:IL-12β2, and IL-12β2:WSX-1. IL-39 was propose...

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Detalles Bibliográficos
Autores principales: Floss, D. M., Schönberg, M., Franke, M., Horstmeier, F. C., Engelowski, E., Schneider, A., Rosenfeldt, E. M., Scheller, J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680241/
https://www.ncbi.nlm.nih.gov/pubmed/29123149
http://dx.doi.org/10.1038/s41598-017-15173-3

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