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Tsg101 chaperone function revealed by HIV-1 assembly inhibitors

HIV-1 replication requires Tsg101, a component of cellular endosomal sorting complex required for transport (ESCRT) machinery. Tsg101 possesses an ubiquitin (Ub) E2 variant (UEV) domain with a pocket that can bind PT/SAP motifs and another pocket that can bind Ub. The PTAP motif in the viral structu...

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Detalles Bibliográficos
Autores principales:	Strickland, Madeleine, Ehrlich, Lorna S., Watanabe, Susan, Khan, Mahfuz, Strub, Marie-Paule, Luan, Chi-Hao, Powell, Michael D., Leis, Jonathan, Tjandra, Nico, Carter, Carol A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680296/ https://www.ncbi.nlm.nih.gov/pubmed/29123089 http://dx.doi.org/10.1038/s41467-017-01426-2

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