Neural-specific deletion of mitochondrial p32/C1qbp leads to leukoencephalopathy due to undifferentiated oligodendrocyte and axon degeneration

Mitochondrial dysfunction is a critical step in the pathogenesis of many neurodegenerative diseases. The p32/ C1qbp gene functions as an essential RNA and protein chaperone in mitochondrial translation, and is indispensable for embryonic development. However, little is known about the consequences o...

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Detalles Bibliográficos
Autores principales: Yagi, Mikako, Uchiumi, Takeshi, Sagata, Noriaki, Setoyama, Daiki, Amamoto, Rie, Matsushima, Yuichi, Kang, Dongchon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680297/
https://www.ncbi.nlm.nih.gov/pubmed/29123152
http://dx.doi.org/10.1038/s41598-017-15414-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680297/
https://www.ncbi.nlm.nih.gov/pubmed/29123152
http://dx.doi.org/10.1038/s41598-017-15414-5

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