A genome-wide association study links small-vessel ischemic stroke to autophagy
Genome-wide association studies (GWAS) can serve as strong evidence in correlating biological pathways with human diseases. Although ischemic stroke has been found to be associated with many biological pathways, the genetic mechanism of ischemic stroke is still unclear. Here, we performed GWAS for a...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680343/ https://www.ncbi.nlm.nih.gov/pubmed/29123153 http://dx.doi.org/10.1038/s41598-017-14355-3 |
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author | Lee, Tsong-Hai Ko, Tai-Ming Chen, Chien-Hsiun Chang, Yeu-Jhy Lu, Liang-Suei Chang, Chien-Hung Huang, Kuo-Lun Chang, Ting-Yu Lee, Jiann-Der Chang, Ku-Chou Yang, Jen-Tsung Wen, Ming-Shien Wang, Chao-Yung Chen, Ying-Ting Chen, Tsai-Chuan Chou, Shu-Yu Lee, Ming-Ta Michael Chen, Yuan-Tsong Wu, Jer-Yuarn |
author_facet | Lee, Tsong-Hai Ko, Tai-Ming Chen, Chien-Hsiun Chang, Yeu-Jhy Lu, Liang-Suei Chang, Chien-Hung Huang, Kuo-Lun Chang, Ting-Yu Lee, Jiann-Der Chang, Ku-Chou Yang, Jen-Tsung Wen, Ming-Shien Wang, Chao-Yung Chen, Ying-Ting Chen, Tsai-Chuan Chou, Shu-Yu Lee, Ming-Ta Michael Chen, Yuan-Tsong Wu, Jer-Yuarn |
author_sort | Lee, Tsong-Hai |
collection | PubMed |
description | Genome-wide association studies (GWAS) can serve as strong evidence in correlating biological pathways with human diseases. Although ischemic stroke has been found to be associated with many biological pathways, the genetic mechanism of ischemic stroke is still unclear. Here, we performed GWAS for a major subtype of stroke—small-vessel occlusion (SVO)—to identify potential genetic factors contributing to ischemic stroke. GWAS were conducted on 342 individuals with SVO stroke and 1,731 controls from a Han Chinese population residing in Taiwan. The study was replicated in an independent Han Chinese population comprising an additional 188 SVO stroke cases and 1,265 controls. Three SNPs (rs2594966, rs2594973, rs4684776) clustered at 3p25.3 in ATG7 (encoding Autophagy Related 7), with P values between 2.52 × 10(−6) and 3.59 × 10(−6), were identified. Imputation analysis also supported the association between ATG7 and SVO stroke. To our knowledge, this is the first GWAS to link stroke and autophagy. ATG7, which has been implicated in autophagy, could provide novel insights into the genetic basis of ischemic stroke. |
format | Online Article Text |
id | pubmed-5680343 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-56803432017-11-17 A genome-wide association study links small-vessel ischemic stroke to autophagy Lee, Tsong-Hai Ko, Tai-Ming Chen, Chien-Hsiun Chang, Yeu-Jhy Lu, Liang-Suei Chang, Chien-Hung Huang, Kuo-Lun Chang, Ting-Yu Lee, Jiann-Der Chang, Ku-Chou Yang, Jen-Tsung Wen, Ming-Shien Wang, Chao-Yung Chen, Ying-Ting Chen, Tsai-Chuan Chou, Shu-Yu Lee, Ming-Ta Michael Chen, Yuan-Tsong Wu, Jer-Yuarn Sci Rep Article Genome-wide association studies (GWAS) can serve as strong evidence in correlating biological pathways with human diseases. Although ischemic stroke has been found to be associated with many biological pathways, the genetic mechanism of ischemic stroke is still unclear. Here, we performed GWAS for a major subtype of stroke—small-vessel occlusion (SVO)—to identify potential genetic factors contributing to ischemic stroke. GWAS were conducted on 342 individuals with SVO stroke and 1,731 controls from a Han Chinese population residing in Taiwan. The study was replicated in an independent Han Chinese population comprising an additional 188 SVO stroke cases and 1,265 controls. Three SNPs (rs2594966, rs2594973, rs4684776) clustered at 3p25.3 in ATG7 (encoding Autophagy Related 7), with P values between 2.52 × 10(−6) and 3.59 × 10(−6), were identified. Imputation analysis also supported the association between ATG7 and SVO stroke. To our knowledge, this is the first GWAS to link stroke and autophagy. ATG7, which has been implicated in autophagy, could provide novel insights into the genetic basis of ischemic stroke. Nature Publishing Group UK 2017-11-09 /pmc/articles/PMC5680343/ /pubmed/29123153 http://dx.doi.org/10.1038/s41598-017-14355-3 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Lee, Tsong-Hai Ko, Tai-Ming Chen, Chien-Hsiun Chang, Yeu-Jhy Lu, Liang-Suei Chang, Chien-Hung Huang, Kuo-Lun Chang, Ting-Yu Lee, Jiann-Der Chang, Ku-Chou Yang, Jen-Tsung Wen, Ming-Shien Wang, Chao-Yung Chen, Ying-Ting Chen, Tsai-Chuan Chou, Shu-Yu Lee, Ming-Ta Michael Chen, Yuan-Tsong Wu, Jer-Yuarn A genome-wide association study links small-vessel ischemic stroke to autophagy |
title | A genome-wide association study links small-vessel ischemic stroke to autophagy |
title_full | A genome-wide association study links small-vessel ischemic stroke to autophagy |
title_fullStr | A genome-wide association study links small-vessel ischemic stroke to autophagy |
title_full_unstemmed | A genome-wide association study links small-vessel ischemic stroke to autophagy |
title_short | A genome-wide association study links small-vessel ischemic stroke to autophagy |
title_sort | genome-wide association study links small-vessel ischemic stroke to autophagy |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680343/ https://www.ncbi.nlm.nih.gov/pubmed/29123153 http://dx.doi.org/10.1038/s41598-017-14355-3 |
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