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Thyroid status and mortality in nonagenarians from long-lived families and the general population

The relationship between thyroid status and longevity has been investigated extensively. However, data on thyroid status and survival in old age is scarce. In this study we investigated associations of different parameters of thyroid status with mortality in nonagenarians, and whether these associat...

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Autores principales: van Vliet, Nicolien A., van der Spoel, Evie, Beekman, Marian, Slagboom, P. Eline, Blauw, Gerard Jan, Gussekloo, Jacobijn, Westendorp, Rudi G.J., van Heemst, Diana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680564/
https://www.ncbi.nlm.nih.gov/pubmed/29070732
http://dx.doi.org/10.18632/aging.101310
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author van Vliet, Nicolien A.
van der Spoel, Evie
Beekman, Marian
Slagboom, P. Eline
Blauw, Gerard Jan
Gussekloo, Jacobijn
Westendorp, Rudi G.J.
van Heemst, Diana
author_facet van Vliet, Nicolien A.
van der Spoel, Evie
Beekman, Marian
Slagboom, P. Eline
Blauw, Gerard Jan
Gussekloo, Jacobijn
Westendorp, Rudi G.J.
van Heemst, Diana
author_sort van Vliet, Nicolien A.
collection PubMed
description The relationship between thyroid status and longevity has been investigated extensively. However, data on thyroid status and survival in old age is scarce. In this study we investigated associations of different parameters of thyroid status with mortality in nonagenarians, and whether these associations were different in nonagenarians from long-lived families than in nonagenarians from the general population. In total, 805 nonagenarians from the Leiden Longevity Study and 259 nonagenarians from the Leiden 85-plus Study were followed up to collect mortality data. At baseline, levels of thyrotropin (TSH), free thyroxine (fT4) and free triiodothyronine (fT3) were measured. In nonagenarians from long-lived families and from the general population, associations between thyroid parameters and mortality were similar. We found no interaction between study population and parameters of thyroid status on mortality (P-values>0.70). The results from both studies were combined to derive generalizable associations. Hazard ratios (HRs) for the highest compared to lowest tertiles were determined, resulting in TSH HR 0.91 (P=0.25), fT4 HR 1.22 (P=0.02), fT3 HR 0.74 (P=1.31e-4), and fT3/fT4 HR 0.66 (P=5.64e-7). In conclusion, higher fT3/fT4 ratios, higher levels of fT3, and lower levels of fT4 were associated with lower mortality rate in nonagenarians and independent of familial longevity status.
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spelling pubmed-56805642017-11-18 Thyroid status and mortality in nonagenarians from long-lived families and the general population van Vliet, Nicolien A. van der Spoel, Evie Beekman, Marian Slagboom, P. Eline Blauw, Gerard Jan Gussekloo, Jacobijn Westendorp, Rudi G.J. van Heemst, Diana Aging (Albany NY) Research Paper The relationship between thyroid status and longevity has been investigated extensively. However, data on thyroid status and survival in old age is scarce. In this study we investigated associations of different parameters of thyroid status with mortality in nonagenarians, and whether these associations were different in nonagenarians from long-lived families than in nonagenarians from the general population. In total, 805 nonagenarians from the Leiden Longevity Study and 259 nonagenarians from the Leiden 85-plus Study were followed up to collect mortality data. At baseline, levels of thyrotropin (TSH), free thyroxine (fT4) and free triiodothyronine (fT3) were measured. In nonagenarians from long-lived families and from the general population, associations between thyroid parameters and mortality were similar. We found no interaction between study population and parameters of thyroid status on mortality (P-values>0.70). The results from both studies were combined to derive generalizable associations. Hazard ratios (HRs) for the highest compared to lowest tertiles were determined, resulting in TSH HR 0.91 (P=0.25), fT4 HR 1.22 (P=0.02), fT3 HR 0.74 (P=1.31e-4), and fT3/fT4 HR 0.66 (P=5.64e-7). In conclusion, higher fT3/fT4 ratios, higher levels of fT3, and lower levels of fT4 were associated with lower mortality rate in nonagenarians and independent of familial longevity status. Impact Journals LLC 2017-10-25 /pmc/articles/PMC5680564/ /pubmed/29070732 http://dx.doi.org/10.18632/aging.101310 Text en Copyright: © 2017 van Vliet et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Research Paper
van Vliet, Nicolien A.
van der Spoel, Evie
Beekman, Marian
Slagboom, P. Eline
Blauw, Gerard Jan
Gussekloo, Jacobijn
Westendorp, Rudi G.J.
van Heemst, Diana
Thyroid status and mortality in nonagenarians from long-lived families and the general population
title Thyroid status and mortality in nonagenarians from long-lived families and the general population
title_full Thyroid status and mortality in nonagenarians from long-lived families and the general population
title_fullStr Thyroid status and mortality in nonagenarians from long-lived families and the general population
title_full_unstemmed Thyroid status and mortality in nonagenarians from long-lived families and the general population
title_short Thyroid status and mortality in nonagenarians from long-lived families and the general population
title_sort thyroid status and mortality in nonagenarians from long-lived families and the general population
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680564/
https://www.ncbi.nlm.nih.gov/pubmed/29070732
http://dx.doi.org/10.18632/aging.101310
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