Cargando…

Increasing AR by HIF-2α inhibitor (PT-2385) overcomes the side-effects of sorafenib by suppressing hepatocellular carcinoma invasion via alteration of pSTAT3, pAKT and pERK signals

Although sorafenib is currently used as a standard treatment for advanced hepatocellular carcinoma, low response rate, transient and limited efficacy, primary and acquired resistance and negative side-effects gain increasing attentions, suggesting the need for better efficacious combination therapy....

Descripción completa

Detalles Bibliográficos
Autores principales:	Xu, Junjie, Zheng, Longbo, Chen, Jiang, Sun, Yin, Lin, Hui, Jin, Ren-an, Tang, Minyue, Liang, Xiao, Cai, Xiujun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680567/ https://www.ncbi.nlm.nih.gov/pubmed/29022906 http://dx.doi.org/10.1038/cddis.2017.411

Ejemplares similares

pERK/pAkt phenotyping in circulating tumor cells as a biomarker for sorafenib efficacy in patients with advanced hepatocellular carcinoma
por: Li, Jun, et al.
Publicado: (2015)

Antiproliferative and Anti-invasion Effects of Carvacrol on PC3 Human Prostate Cancer Cells through Reducing pSTAT3, pAKT, and pERK1/2 Signaling Proteins
por: Heidarian, Esfandiar, et al.
Publicado: (2019)

Imatinib Mesylate Reduces Neurotrophic Factors and pERK and pAKT Expression in Urinary Bladder of Female Mice With Cyclophosphamide-Induced Cystitis
por: Perkins, Megan, et al.
Publicado: (2022)

Loss of Bmp2 impairs odontogenesis via dysregulating pAkt/pErk/GCN5/Dlx3/Sp7
por: Chen, Shuo, et al.
Publicado: (2023)

Clinical significance of pAkt and pErk1/2 expression in early-stage breast cancer patients treated with anthracycline-based adjuvant chemotherapy
por: LIU, WENJUAN, et al.
Publicado: (2015)

pERK, pAKT and p53 as tissue biomarkers in erlotinib-treated patients with advanced pancreatic cancer: a translational subgroup analysis from AIO-PK0104
por: Ormanns, Steffen, et al.
Publicado: (2014)

IFI35 Promotes Renal Cancer Progression by Inhibiting pSTAT1/pSTAT6-Dependent Autophagy
por: Chai, Dafei, et al.
Publicado: (2022)

Sorafenib with ASC‐J9(®) synergistically suppresses the HCC progression via altering the pSTAT3‐CCL2/Bcl2 signals
por: Xu, Junjie, et al.
Publicado: (2016)

Predicting the response to sorafenib in hepatocellular carcinoma: where is the evidence for phosphorylated extracellular signaling-regulated kinase (pERK)?
por: Zhu, Andrew X
Publicado: (2009)

Protective Effects of Hif2 Inhibitor PT-2385 on a Neurological Disorder Induced by Deficiency of Irp2
por: Shen, Jiaqi, et al.
Publicado: (2021)

Direct targets of pSTAT5 signalling in erythropoiesis
por: Gillinder, Kevin R., et al.
Publicado: (2017)

Expression of tSTAT3, pSTAT3(727), and pSTAT3 (705) in the epithelial cells of hormone‐naïve prostate cancer
por: Krzyzanowska, Agnieszka, et al.
Publicado: (2019)

Effective Perturbations of the Amplitude, Gating, and Hysteresis of I(K(DR)) Caused by PT-2385, an HIF-2α Inhibitor
por: Hsiao, Hung-Tsung, et al.
Publicado: (2021)

Potential Refinement of Recurrence Score by pSTAT3 Status
por: Grinshpun, Albert, et al.
Publicado: (2022)

Expression of the Androgen Receptor, pAkt, and pPTEN in Breast Cancer and Their Potential in Prognostication()
por: Sultana, Aisha, et al.
Publicado: (2014)

pSTAT1 Is Activated during the Progression of IgA Nephropathy
por: Tao, Jianling, et al.
Publicado: (2022)

ERK/pERK expression and B-raf mutations in colon adenocarcinomas: correlation with clinicopathological characteristics
por: Levidou, Georgia, et al.
Publicado: (2012)

Increased expression of pAKT is associated with radiation resistance in cervical cancer
por: Kim, T-J, et al.
Publicado: (2006)

Doxorubicin Induces Cytotoxicity through Upregulation of pERK–Dependent ATF3
por: Park, Eun-Jung, et al.
Publicado: (2012)

Neurochemical characterization of pERK-expressing spinal neurons in histamine-induced itch
por: Jiang, Guan-Yu, et al.
Publicado: (2015)

Prognostic Significance of B-Cells and pSTAT3 in Patients with Ovarian Cancer
por: Yang, Chunmei, et al.
Publicado: (2013)

A NANOG‐pERK reciprocal regulatory circuit regulates Nanog autoregulation and ERK signaling dynamics
por: Kale, Hanuman T, et al.
Publicado: (2022)

Modulation of signaling cross-talk between pJNK and pAKT generates optimal apoptotic response
por: Biswas, Sharmila, et al.
Publicado: (2022)

The assessment of correlation and prognosis among (18)F-FDG uptake parameters, Glut1, pStat1 and pStat3 in surgically resected non-small cell lung cancer patients
por: Kaida, Hayato, et al.
Publicado: (2018)

Enhancement of Anxiety and Modulation of TH and pERK Expressions in Amygdala by Repeated Injections of Corticosterone
por: Lim, Heena, et al.
Publicado: (2012)

Using pERK immunostaining to quantify neuronal activity induced by stress in zebrafish larvae
por: Corradi, Laura, et al.
Publicado: (2022)

Inhibition of pSTAT1 by tofacitinib accounts for the early improvement of experimental chronic synovitis
por: Pérez-Baos, Sandra, et al.
Publicado: (2019)

Dynamic Changes in pStat3 Are Involved in Meiotic Spindle Assembly in Mouse Oocytes
por: Haraguchi, Seiki, et al.
Publicado: (2020)

Chronic tooth pulp inflammation induces persistent expression of phosphorylated ERK (pERK) and phosphorylated p38 (pp38) in trigeminal subnucleus caudalis
por: Worsley, M.A., et al.
Publicado: (2014)

The functional interlink between AR and MMP9/VEGF signaling axis is mediated through PIP5K1α/pAKT in prostate cancer
por: Larsson, Per, et al.
Publicado: (2019)

Connectivity of corticostriatal circuits in nonmanifesting LRRK2 G2385R and R1628P carriers
por: Zhang, Dongling, et al.
Publicado: (2022)

Erythropoietin receptor regulates tumor mitochondrial biogenesis through iNOS and pAKT
por: Aboouf, Mostafa A., et al.
Publicado: (2022)

Expression of pAkt affects p53 codon 72 polymorphism-based prediction of response to radiotherapy in nasopharyngeal carcinoma
por: Xie, Xiaoxue, et al.
Publicado: (2013)

Formononetin Inhibits Progression of Endometriosis via Regulation of p27, pSTAT3, and Progesterone Receptor: In Vitro and In Vivo Studies
por: Park, Yunjeong, et al.
Publicado: (2023)

Histology-dependent prognostic role of pERK and p53 protein levels in early-stage non-small cell lung cancer
por: Quintanal-Villalonga, Álvaro, et al.
Publicado: (2018)

Adiponectin receptor agonists inhibit leptin induced pSTAT3 and in vivo pancreatic tumor growth
por: Messaggio, Fanuel, et al.
Publicado: (2017)

A biscarbene gold(I)-NHC-complex overcomes cisplatin-resistance in A2780 and W1 ovarian cancer cells highlighting pERK as regulator of apoptosis
por: König, Philipp, et al.
Publicado: (2023)

CELLFOOD™ induces apoptosis in human mesothelioma and colorectal cancer cells by modulating p53, c-myc and pAkt signaling pathways
por: Nuvoli, Barbara, et al.
Publicado: (2014)

Analgesic Effect of Electroacupuncture in a Mouse Fibromyalgia Model: Roles of TRPV1, TRPV4, and pERK
por: Lin, Jaung-Geng, et al.
Publicado: (2015)

Increased HMGB1 expression correlates with higher expression of c-IAP2 and pERK in colorectal cancer
por: Zhang, Wenjia, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_hc0atjfhtu6nfjtba3395s8tt3