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Targeting redox homeostasis in rhabdomyosarcoma cells: GSH-depleting agents enhance auranofin-induced cell death
Rhabdomyosarcoma (RMS) cells have recently been reported to be sensitive to oxidative stress. Therefore, we investigated whether concomitant inhibition of the two main antioxidant defense pathways, that is, the thioredoxin (TRX) and the glutathione (GSH) systems, presents a new strategy to trigger c...
Autores principales: | Habermann, Karoline Johanna, Grünewald, Leon, van Wijk, Sjoerd, Fulda, Simone |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680568/ https://www.ncbi.nlm.nih.gov/pubmed/28981107 http://dx.doi.org/10.1038/cddis.2017.412 |
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