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Targeting redox homeostasis in rhabdomyosarcoma cells: GSH-depleting agents enhance auranofin-induced cell death

Rhabdomyosarcoma (RMS) cells have recently been reported to be sensitive to oxidative stress. Therefore, we investigated whether concomitant inhibition of the two main antioxidant defense pathways, that is, the thioredoxin (TRX) and the glutathione (GSH) systems, presents a new strategy to trigger c...

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Detalles Bibliográficos
Autores principales:	Habermann, Karoline Johanna, Grünewald, Leon, van Wijk, Sjoerd, Fulda, Simone
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680568/ https://www.ncbi.nlm.nih.gov/pubmed/28981107 http://dx.doi.org/10.1038/cddis.2017.412

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