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Treatment with A(2A) receptor antagonist KW6002 and caffeine intake regulate microglia reactivity and protect retina against transient ischemic damage
Transient retinal ischemia is a major complication of retinal degenerative diseases and contributes to visual impairment and blindness. Evidences indicate that microglia-mediated neuroinflammation has a key role in the neurodegenerative process, prompting the hypothesis that the control of microglia...
Autores principales: | Boia, Raquel, Elvas, Filipe, Madeira, Maria H, Aires, Inês D, Rodrigues-Neves, Ana C, Tralhão, Pedro, Szabó, Eszter C, Baqi, Younis, Müller, Christa E, Tomé, Ângelo R, Cunha, Rodrigo A, Ambrósio, António F, Santiago, Ana R |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680573/ https://www.ncbi.nlm.nih.gov/pubmed/28981089 http://dx.doi.org/10.1038/cddis.2017.451 |
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