Cargando…

Dexamethasone mediates pancreatic cancer progression by glucocorticoid receptor, TGFβ and JNK/AP-1

Glucocorticoids such as dexamethasone are widely co-prescribed with cytotoxic therapy because of their proapoptotic effects in lymphoid cancer, reduction of inflammation and edema and additional benefits. Concerns about glucocorticoid-induced therapy resistance, enhanced metastasis and reduced survi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Li, Aleksandrowicz, Ewa, Schönsiegel, Frank, Gröner, Daniel, Bauer, Nathalie, Nwaeburu, Clifford C, Zhao, Zhefu, Gladkich, Jury, Hoppe-Tichy, Torsten, Yefenof, Eitan, Hackert, Thilo, Strobel, Oliver, Herr, Ingrid
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680577/ https://www.ncbi.nlm.nih.gov/pubmed/28981109 http://dx.doi.org/10.1038/cddis.2017.455

Ejemplares similares

Dexamethasone-induced inhibition of miR-132 via methylation promotes TGF-β-driven progression of pancreatic cancer
por: Abukiwan, Alia, et al.
Publicado: (2018)

Dexamethasone-induced inhibition of miR-132 via methylation promotes TGF-β-driven progression of pancreatic cancer
por: Abukiwan, Alia, et al.
Publicado: (2023)

Intraductal papillary mucinous neoplasm of the pancreas rapidly xenografts in chicken eggs and predicts aggressiveness
por: Zhao, Zhefu, et al.
Publicado: (2017)

Up-regulation of microRNA let-7c by quercetin inhibits pancreatic cancer progression by activation of Numbl
por: Nwaeburu, Clifford C., et al.
Publicado: (2016)

Sulforaphane and TRAIL induce a synergistic elimination of advanced prostate cancer stem-like cells
por: LABSCH, SABRINA, et al.
Publicado: (2014)

Glucocorticoid-induced microRNA-378 signaling mediates the progression of pancreatic cancer by enhancing autophagy
por: Liu, Li, et al.
Publicado: (2022)

Delivery of improved oncolytic adenoviruses by mesenchymal stromal cells for elimination of tumorigenic pancreatic cancer cells
por: Kaczorowski, Adam, et al.
Publicado: (2016)

Triptolide reverses hypoxia-induced epithelial–mesenchymal transition and stem-like features in pancreatic cancer by NF-κB downregulation
por: Liu, Li, et al.
Publicado: (2014)

The novel c-Met inhibitor cabozantinib overcomes gemcitabine resistance and stem cell signaling in pancreatic cancer
por: Hage, C, et al.
Publicado: (2013)

Quercetin-induced miR-200b-3p regulates the mode of self-renewing divisions in pancreatic cancer
por: Nwaeburu, Clifford C., et al.
Publicado: (2017)

Retraction Note: Quercetin-induced miR-200b-3p regulates the mode of self-renewing divisions in pancreatic cancer
por: Nwaeburu, Clifford C., et al.
Publicado: (2023)

Inhibition of glucose turnover by 3-bromopyruvate counteracts pancreatic cancer stem cell features and sensitizes cells to gemcitabine
por: Isayev, Orkhan, et al.
Publicado: (2014)

Role of mitochondrial glucocorticoid receptor in glucocorticoid-induced apoptosis
por: Sionov, Ronit Vogt, et al.
Publicado: (2006)

Enrichment of c-Met(+) tumorigenic stromal cells of giant cell tumor of bone and targeting by cabozantinib
por: Liu, L, et al.
Publicado: (2014)

Aspirin counteracts cancer stem cell features, desmoplasia and gemcitabine resistance in pancreatic cancer
por: Zhang, Yiyao, et al.
Publicado: (2015)

Glucocorticoids Antagonize Ap-1 by Inhibiting the Activation/Phosphorylation of Jnk without Affecting Its Subcellular Distribution
por: González, María Victoria, et al.
Publicado: (2000)

miR-103 inhibits proliferation and sensitizes hemopoietic tumor cells for glucocorticoid-induced apoptosis
por: Kfir-Erenfeld, Shlomit, et al.
Publicado: (2016)

UHMK1 Is a Novel Marker for Personalized Prediction of Pancreatic Cancer Prognosis
por: Luo, Yiqiao, et al.
Publicado: (2022)

Sulforaphane counteracts aggressiveness of pancreatic cancer driven by dysregulated Cx43-mediated gap junctional intercellular communication
por: Forster, Tobias, et al.
Publicado: (2014)

Sulforaphane Induces miR135b-5p and Its Target Gene, RASAL2, thereby Inhibiting the Progression of Pancreatic Cancer
por: Yin, Libo, et al.
Publicado: (2019)

Synaptic and genomic responses to JNK and AP-1 signaling in Drosophila neurons
por: Etter, Paul D, et al.
Publicado: (2005)

Interaction of Glucocorticoid Receptor (GR) with Estrogen Receptor (ER) α and Activator Protein 1 (AP1) in Dexamethasone-mediated Interference of ERα Activity
por: Karmakar, Sudipan, et al.
Publicado: (2013)

Serum cholesterol selectively regulates glucocorticoid sensitivity through activation of JNK
por: Yang, Nan, et al.
Publicado: (2014)

Sulforaphane Targets TRA-1/GLI Upstream of DAF-16/FOXO to Promote C. elegans Longevity and Healthspan
por: Ji, Huihui, et al.
Publicado: (2021)

A Role for Bcl-2 in Notch1-Dependent Transcription in Thymic Lymphoma Cells
por: Sionov, Ronit Vogt, et al.
Publicado: (2012)

Endothelial glucocorticoid receptor promoter methylation according to dexamethasone sensitivity
por: Mata-Greenwood, Eugenia, et al.
Publicado: (2015)

Sulforaphane Inhibits the Expression of Long Noncoding RNA H19 and Its Target APOBEC3G and Thereby Pancreatic Cancer Progression
por: Luo, Yiqiao, et al.
Publicado: (2021)

Alpha-Lipoic Acid Prevents Side Effects of Therapeutic Nanosilver without Compromising Cytotoxicity in Experimental Pancreatic Cancer
por: An, Xuefeng, et al.
Publicado: (2021)

Novel plant microRNAs from broccoletti sprouts do not show cross-kingdom regulation of pancreatic cancer
por: Xiao, Xi, et al.
Publicado: (2020)

Taurochenodeoxycholic Acid Inhibited AP-1 Activation via Stimulating Glucocorticoid Receptor
por: Li, Lei, et al.
Publicado: (2019)

Dexamethasone Therapy of Congenital Adrenal Hyperplasia and the Myth of the “Growth Toxic” Glucocorticoid
por: Rivkees, Scott A.
Publicado: (2010)

Regulation of the antiapoptotic protein cFLIP by the glucocorticoid Dexamethasone in ALL cells
por: Kleinesudeik, Lara, et al.
Publicado: (2018)

Transcriptome Responses to Dexamethasone Depending on Dose and Glucocorticoid Receptor Sensitivity in the Liver
por: Murani, Eduard, et al.
Publicado: (2019)

Biochemical and morphological attributes of broiler kidney in response to dietary glucocorticoid, dexamethasone
por: Sultana, Nasrin, et al.
Publicado: (2021)

RNA binding by the glucocorticoid receptor attenuates dexamethasone-induced gene activation
por: Lammer, Nickolaus C., et al.
Publicado: (2023)

CCR7 mediates the TNF-α-induced lymphatic metastasis of gallbladder cancer through the “ERK1/2 - AP-1” and “JNK - AP-1” pathways
por: Hong, HaiJie, et al.
Publicado: (2016)

Role of the JNK/c-Jun/AP-1 signaling pathway in galectin-1-induced T-cell death
por: Brandt, B, et al.
Publicado: (2010)

Therapeutic targeting of pancreatic cancer stem cells by dexamethasone modulation of the MKP-1–JNK axis
por: Suzuki, Shuhei, et al.
Publicado: (2021)

Glucocorticoid Receptor α Mediates Roflumilast’s Ability to Restore Dexamethasone Sensitivity in COPD
por: Reddy, Aravind T, et al.
Publicado: (2020)

Glucocorticoids dexamethasone and prednisolone suppress fibroblast growth factor 23 (FGF23)
por: Feger, Martina, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_pum7kdmhesoc1alrt5qe5eepb3