Superoxide drives progression of Parkin/PINK1-dependent mitophagy following translocation of Parkin to mitochondria

Reactive oxygen species (ROS) and mitophagy are profoundly implicated in the pathogenesis of neurodegenerative diseases, such as Parkinson’s disease (PD). Several studies have suggested that ROS are not involved in mitochondrial translocation of Parkin which primes mitochondria for autophagic elimin...

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Detalles Bibliográficos
Autores principales: Xiao, Bin, Deng, Xiao, Lim, Grace G Y, Xie, Shaoping, Zhou, Zhi Dong, Lim, Kah-Leong, Tan, Eng-King
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680585/
https://www.ncbi.nlm.nih.gov/pubmed/29022898
http://dx.doi.org/10.1038/cddis.2017.463

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