Berberine induces oxidative DNA damage and impairs homologous recombination repair in ovarian cancer cells to confer increased sensitivity to PARP inhibition

Many cancer drugs exert their therapeutic effect by inducing oxidative stress in the cancer cells. Oxidative stress compromises cell survival by inflicting lesions in macromolecules like DNA. Cancer cells rely on enhanced antioxidant metabolism and increased DNA repair function to survive oxidative...

Descripción completa

Detalles Bibliográficos
Autores principales: Hou, Dong, Xu, Guangwei, Zhang, Caibo, Li, Boxuan, Qin, Junchao, Hao, Xiaohe, Liu, Qiao, Zhang, Xiyu, Liu, Jinsong, Wei, Jianjun, Gong, Yaoqin, Liu, Zhaojian, Shao, Changshun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680592/
https://www.ncbi.nlm.nih.gov/pubmed/28981112
http://dx.doi.org/10.1038/cddis.2017.471

Ejemplares similares

Ejemplares similares