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The effect of adding ferrous sulfate to methylphenidate on attention-deficit/hyperactivity disorder in children
Attention deficit/hyperactivity disorder (ADHD) is one of the most common psychiatric disorders in children with several complications. This study was conducted to investigate the effect of adding ferrous sulfate to methylphenidate in decreasing ADHD symptoms. This study was a double-blind, randomiz...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680621/ https://www.ncbi.nlm.nih.gov/pubmed/29184845 http://dx.doi.org/10.4103/japtr.JAPTR_45_17 |
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author | Panahandeh, Gholamreza Vatani, Bahareh Safavi, Parvin Khoshdel, Abolfazl |
author_facet | Panahandeh, Gholamreza Vatani, Bahareh Safavi, Parvin Khoshdel, Abolfazl |
author_sort | Panahandeh, Gholamreza |
collection | PubMed |
description | Attention deficit/hyperactivity disorder (ADHD) is one of the most common psychiatric disorders in children with several complications. This study was conducted to investigate the effect of adding ferrous sulfate to methylphenidate in decreasing ADHD symptoms. This study was a double-blind, randomized clinical trial. In this study, 42 nonanemic children with ADHD and serum ferritin below 30 mg/ml were enrolled according to convenience sampling and randomly assigned to two groups of 21 each, cases and controls. The two groups were matched for age and sex. The case group was administered with ferrous sulfate 5 mg/kg in addition to methylphenidate up to 1 mg/kg and the control group with methylphenidate alone. The scores on child symptoms inventory-4 (CSI-4) were recorded at baseline and after 2 months of treatment. Data were analyzed by t-test, Pearson's correlation coefficient, and repeated measures ANOVA in SPSS 16. The scores on CSI-4 decreased significantly at month 2 in both groups (P < 0.001). The scores on attention deficit and hyperactivity subscales of the CSI-4 were significantly lower in the case group than the control group (P < 0.05). The total score on CSI-4 decreased more markedly in the case group (P < 0.04). Use of ferrous sulfate plus methylphenidate can be effective in reducing ADHD symptoms in nonanemic children with low serum ferritin. |
format | Online Article Text |
id | pubmed-5680621 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-56806212017-11-28 The effect of adding ferrous sulfate to methylphenidate on attention-deficit/hyperactivity disorder in children Panahandeh, Gholamreza Vatani, Bahareh Safavi, Parvin Khoshdel, Abolfazl J Adv Pharm Technol Res Original Article Attention deficit/hyperactivity disorder (ADHD) is one of the most common psychiatric disorders in children with several complications. This study was conducted to investigate the effect of adding ferrous sulfate to methylphenidate in decreasing ADHD symptoms. This study was a double-blind, randomized clinical trial. In this study, 42 nonanemic children with ADHD and serum ferritin below 30 mg/ml were enrolled according to convenience sampling and randomly assigned to two groups of 21 each, cases and controls. The two groups were matched for age and sex. The case group was administered with ferrous sulfate 5 mg/kg in addition to methylphenidate up to 1 mg/kg and the control group with methylphenidate alone. The scores on child symptoms inventory-4 (CSI-4) were recorded at baseline and after 2 months of treatment. Data were analyzed by t-test, Pearson's correlation coefficient, and repeated measures ANOVA in SPSS 16. The scores on CSI-4 decreased significantly at month 2 in both groups (P < 0.001). The scores on attention deficit and hyperactivity subscales of the CSI-4 were significantly lower in the case group than the control group (P < 0.05). The total score on CSI-4 decreased more markedly in the case group (P < 0.04). Use of ferrous sulfate plus methylphenidate can be effective in reducing ADHD symptoms in nonanemic children with low serum ferritin. Medknow Publications & Media Pvt Ltd 2017 /pmc/articles/PMC5680621/ /pubmed/29184845 http://dx.doi.org/10.4103/japtr.JAPTR_45_17 Text en Copyright: © 2017 Journal of Advanced Pharmaceutical Technology & Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Panahandeh, Gholamreza Vatani, Bahareh Safavi, Parvin Khoshdel, Abolfazl The effect of adding ferrous sulfate to methylphenidate on attention-deficit/hyperactivity disorder in children |
title | The effect of adding ferrous sulfate to methylphenidate on attention-deficit/hyperactivity disorder in children |
title_full | The effect of adding ferrous sulfate to methylphenidate on attention-deficit/hyperactivity disorder in children |
title_fullStr | The effect of adding ferrous sulfate to methylphenidate on attention-deficit/hyperactivity disorder in children |
title_full_unstemmed | The effect of adding ferrous sulfate to methylphenidate on attention-deficit/hyperactivity disorder in children |
title_short | The effect of adding ferrous sulfate to methylphenidate on attention-deficit/hyperactivity disorder in children |
title_sort | effect of adding ferrous sulfate to methylphenidate on attention-deficit/hyperactivity disorder in children |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680621/ https://www.ncbi.nlm.nih.gov/pubmed/29184845 http://dx.doi.org/10.4103/japtr.JAPTR_45_17 |
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