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Association between oxidative stress and cord serum lipids in relation to delayed cord clamping in term neonates
BACKGROUND: Although delayed cord clamping (DCC) is a recent WHO recommendation, early cord clamping (ECC) is still a routine practice in many countries. Limited researches studied the effect of delayed cord clamping on oxidative stress in term neonates; In this study we aim to assess the influence...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680750/ https://www.ncbi.nlm.nih.gov/pubmed/29121952 http://dx.doi.org/10.1186/s12944-017-0599-y |
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author | Moustafa, Asmaa N. Ibrahim, Mahmoud H. Mousa, Suzan Omar Hassan, Ebtesam E. Mohamed, Hashem F. Moness, Hend M. |
author_facet | Moustafa, Asmaa N. Ibrahim, Mahmoud H. Mousa, Suzan Omar Hassan, Ebtesam E. Mohamed, Hashem F. Moness, Hend M. |
author_sort | Moustafa, Asmaa N. |
collection | PubMed |
description | BACKGROUND: Although delayed cord clamping (DCC) is a recent WHO recommendation, early cord clamping (ECC) is still a routine practice in many countries. Limited researches studied the effect of delayed cord clamping on oxidative stress in term neonates; In this study we aim to assess the influence of cord clamping either early or late on oxidative stress in term neonates and to evaluate the association of oxidative stress and cord blood lipids. METHODS: One-hundred mothers and their term neonates were included in the present study. Umbilical cord blood samples were collected from the umbilical vein and umbilical artery immediately following labor. RESULTS: Total cholesterol, total triglycerides and phospholipids levels were significantly higher in the ECC group than the DCC group (p < 0.001 in all). Plasma total antioxidant status was higher in the DCC group than the ECC group (p < 0.001). While, plasma hydroperoxides were lower in the DCC group than the ECC group (p < 0.001). Levels of erythrocytes catalase cytosol, superoxide dismutase and glutathione peroxidase were significantly higher in the DCC group than the ECC group (p < 0.001). CONCLUSION: DCC was associated with a decrease in cord blood lipids and an augmented antioxidant activity. This suggests the protective effect of DCC on the future health of the term neonates and supports the application of DCC in active management of 3rd stage of labor in term neonates. |
format | Online Article Text |
id | pubmed-5680750 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-56807502017-11-17 Association between oxidative stress and cord serum lipids in relation to delayed cord clamping in term neonates Moustafa, Asmaa N. Ibrahim, Mahmoud H. Mousa, Suzan Omar Hassan, Ebtesam E. Mohamed, Hashem F. Moness, Hend M. Lipids Health Dis Research BACKGROUND: Although delayed cord clamping (DCC) is a recent WHO recommendation, early cord clamping (ECC) is still a routine practice in many countries. Limited researches studied the effect of delayed cord clamping on oxidative stress in term neonates; In this study we aim to assess the influence of cord clamping either early or late on oxidative stress in term neonates and to evaluate the association of oxidative stress and cord blood lipids. METHODS: One-hundred mothers and their term neonates were included in the present study. Umbilical cord blood samples were collected from the umbilical vein and umbilical artery immediately following labor. RESULTS: Total cholesterol, total triglycerides and phospholipids levels were significantly higher in the ECC group than the DCC group (p < 0.001 in all). Plasma total antioxidant status was higher in the DCC group than the ECC group (p < 0.001). While, plasma hydroperoxides were lower in the DCC group than the ECC group (p < 0.001). Levels of erythrocytes catalase cytosol, superoxide dismutase and glutathione peroxidase were significantly higher in the DCC group than the ECC group (p < 0.001). CONCLUSION: DCC was associated with a decrease in cord blood lipids and an augmented antioxidant activity. This suggests the protective effect of DCC on the future health of the term neonates and supports the application of DCC in active management of 3rd stage of labor in term neonates. BioMed Central 2017-11-09 /pmc/articles/PMC5680750/ /pubmed/29121952 http://dx.doi.org/10.1186/s12944-017-0599-y Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Moustafa, Asmaa N. Ibrahim, Mahmoud H. Mousa, Suzan Omar Hassan, Ebtesam E. Mohamed, Hashem F. Moness, Hend M. Association between oxidative stress and cord serum lipids in relation to delayed cord clamping in term neonates |
title | Association between oxidative stress and cord serum lipids in relation to delayed cord clamping in term neonates |
title_full | Association between oxidative stress and cord serum lipids in relation to delayed cord clamping in term neonates |
title_fullStr | Association between oxidative stress and cord serum lipids in relation to delayed cord clamping in term neonates |
title_full_unstemmed | Association between oxidative stress and cord serum lipids in relation to delayed cord clamping in term neonates |
title_short | Association between oxidative stress and cord serum lipids in relation to delayed cord clamping in term neonates |
title_sort | association between oxidative stress and cord serum lipids in relation to delayed cord clamping in term neonates |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680750/ https://www.ncbi.nlm.nih.gov/pubmed/29121952 http://dx.doi.org/10.1186/s12944-017-0599-y |
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