Cargando…
Case definition terminology for paratuberculosis (Johne’s disease)
Paratuberculosis (Johne’s disease) is an economically significant condition caused by Mycobacterium avium subsp. paratuberculosis. However, difficulties in diagnosis and classification of individual animals with the condition have hampered research and impeded efforts to halt its progressive spread...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680782/ https://www.ncbi.nlm.nih.gov/pubmed/29121939 http://dx.doi.org/10.1186/s12917-017-1254-6 |
_version_ | 1783277826671116288 |
---|---|
author | Whittington, R. J. Begg, D. J. de Silva, K. Purdie, A. C. Dhand, N. K. Plain, K. M. |
author_facet | Whittington, R. J. Begg, D. J. de Silva, K. Purdie, A. C. Dhand, N. K. Plain, K. M. |
author_sort | Whittington, R. J. |
collection | PubMed |
description | Paratuberculosis (Johne’s disease) is an economically significant condition caused by Mycobacterium avium subsp. paratuberculosis. However, difficulties in diagnosis and classification of individual animals with the condition have hampered research and impeded efforts to halt its progressive spread in the global livestock industry. Descriptive terms applied to individual animals and herds such as exposed, infected, diseased, clinical, sub-clinical, infectious and resistant need to be defined so that they can be incorporated consistently into well-understood and reproducible case definitions. These allow for consistent classification of individuals in a population for the purposes of analysis based on accurate counts. The outputs might include the incidence of cases, frequency distributions of the number of cases by age class or more sophisticated analyses involving statistical comparisons of immune responses in vaccine development studies, or gene frequencies or expression data from cases and controls in genomic investigations. It is necessary to have agreed definitions in order to be able to make valid comparisons and meta-analyses of experiments conducted over time by a given researcher, in different laboratories, by different researchers, and in different countries. In this paper, terms are applied systematically in an hierarchical flow chart to enable classification of individual animals. We propose descriptive terms for different stages in the pathogenesis of paratuberculosis to enable their use in different types of studies and to enable an independent assessment of the extent to which accepted definitions for stages of disease have been applied consistently in any given study. This will assist in the general interpretation of data between studies, and will facilitate future meta-analyses. |
format | Online Article Text |
id | pubmed-5680782 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-56807822017-11-17 Case definition terminology for paratuberculosis (Johne’s disease) Whittington, R. J. Begg, D. J. de Silva, K. Purdie, A. C. Dhand, N. K. Plain, K. M. BMC Vet Res Correspondence Paratuberculosis (Johne’s disease) is an economically significant condition caused by Mycobacterium avium subsp. paratuberculosis. However, difficulties in diagnosis and classification of individual animals with the condition have hampered research and impeded efforts to halt its progressive spread in the global livestock industry. Descriptive terms applied to individual animals and herds such as exposed, infected, diseased, clinical, sub-clinical, infectious and resistant need to be defined so that they can be incorporated consistently into well-understood and reproducible case definitions. These allow for consistent classification of individuals in a population for the purposes of analysis based on accurate counts. The outputs might include the incidence of cases, frequency distributions of the number of cases by age class or more sophisticated analyses involving statistical comparisons of immune responses in vaccine development studies, or gene frequencies or expression data from cases and controls in genomic investigations. It is necessary to have agreed definitions in order to be able to make valid comparisons and meta-analyses of experiments conducted over time by a given researcher, in different laboratories, by different researchers, and in different countries. In this paper, terms are applied systematically in an hierarchical flow chart to enable classification of individual animals. We propose descriptive terms for different stages in the pathogenesis of paratuberculosis to enable their use in different types of studies and to enable an independent assessment of the extent to which accepted definitions for stages of disease have been applied consistently in any given study. This will assist in the general interpretation of data between studies, and will facilitate future meta-analyses. BioMed Central 2017-11-09 /pmc/articles/PMC5680782/ /pubmed/29121939 http://dx.doi.org/10.1186/s12917-017-1254-6 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Correspondence Whittington, R. J. Begg, D. J. de Silva, K. Purdie, A. C. Dhand, N. K. Plain, K. M. Case definition terminology for paratuberculosis (Johne’s disease) |
title | Case definition terminology for paratuberculosis (Johne’s disease) |
title_full | Case definition terminology for paratuberculosis (Johne’s disease) |
title_fullStr | Case definition terminology for paratuberculosis (Johne’s disease) |
title_full_unstemmed | Case definition terminology for paratuberculosis (Johne’s disease) |
title_short | Case definition terminology for paratuberculosis (Johne’s disease) |
title_sort | case definition terminology for paratuberculosis (johne’s disease) |
topic | Correspondence |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680782/ https://www.ncbi.nlm.nih.gov/pubmed/29121939 http://dx.doi.org/10.1186/s12917-017-1254-6 |
work_keys_str_mv | AT whittingtonrj casedefinitionterminologyforparatuberculosisjohnesdisease AT beggdj casedefinitionterminologyforparatuberculosisjohnesdisease AT desilvak casedefinitionterminologyforparatuberculosisjohnesdisease AT purdieac casedefinitionterminologyforparatuberculosisjohnesdisease AT dhandnk casedefinitionterminologyforparatuberculosisjohnesdisease AT plainkm casedefinitionterminologyforparatuberculosisjohnesdisease |