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Suppressing allostery in epitope mapping experiments using millisecond hydrogen / deuterium exchange mass spectrometry

Localization of the interface between the candidate antibody and its antigen target, commonly known as epitope mapping, is a critical component of the development of therapeutic monoclonal antibodies. With the recent availability of commercial automated systems, hydrogen / deuterium eXchange (HDX) i...

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Detalles Bibliográficos
Autores principales:	Deng, Bin, Zhu, Shaolong, Macklin, Andrew M., Xu, Jianrong, Lento, Cristina, Sljoka, Adnan, Wilson, Derek J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2017
Materias:	Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680795/ https://www.ncbi.nlm.nih.gov/pubmed/28933661 http://dx.doi.org/10.1080/19420862.2017.1379641

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