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Individual and household characteristics of persons with Plasmodium falciparum malaria in sites with varying endemicities in Kinshasa Province, Democratic Republic of the Congo

BACKGROUND: The Democratic Republic of the Congo (DRC) bears a large share of global malaria burden despite efforts to control and eliminate the disease. More detailed understanding of individual and household level characteristics associated with malaria are needed, as is an understanding of how th...

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Autores principales: Mwandagalirwa, Melchior Kashamuka, Levitz, Lauren, Thwai, Kyaw L., Parr, Jonathan B., Goel, Varun, Janko, Mark, Tshefu, Antoinette, Emch, Michael, Meshnick, Steven R., Carrel, Margaret
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680818/
https://www.ncbi.nlm.nih.gov/pubmed/29121931
http://dx.doi.org/10.1186/s12936-017-2110-7
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author Mwandagalirwa, Melchior Kashamuka
Levitz, Lauren
Thwai, Kyaw L.
Parr, Jonathan B.
Goel, Varun
Janko, Mark
Tshefu, Antoinette
Emch, Michael
Meshnick, Steven R.
Carrel, Margaret
author_facet Mwandagalirwa, Melchior Kashamuka
Levitz, Lauren
Thwai, Kyaw L.
Parr, Jonathan B.
Goel, Varun
Janko, Mark
Tshefu, Antoinette
Emch, Michael
Meshnick, Steven R.
Carrel, Margaret
author_sort Mwandagalirwa, Melchior Kashamuka
collection PubMed
description BACKGROUND: The Democratic Republic of the Congo (DRC) bears a large share of global malaria burden despite efforts to control and eliminate the disease. More detailed understanding of individual and household level characteristics associated with malaria are needed, as is an understanding of how these characteristics vary spatiotemporally and across different community-level malaria endemicities. An ongoing study in Kinshasa Province is designed to address gaps in prior malaria surveillance in the DRC by monitoring malaria across seasons, age groups and in high and low malaria sites. Across seven sites, 242 households and 1591 individuals are participating in the study. Results of the enrollment questionnaire, rapid diagnostic tests and PCR testing of dried blood spots are presented. RESULTS: Overall malaria prevalence in the study cohort is high, 27% by rapid diagnostic test and 31% by polymerase chain reaction, and malaria prevalence is highly varied across very small geographic distances. Malaria prevalence is highest in children aged 6–15. While the majority of households own bed nets, bed net usage is less than 50%. CONCLUSIONS: The study cohort will provide an understanding of how malaria persists in populations that have varying environmental exposures, varying community-level malaria, and varying access to malaria control efforts. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12936-017-2110-7) contains supplementary material, which is available to authorized users.
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spelling pubmed-56808182017-11-17 Individual and household characteristics of persons with Plasmodium falciparum malaria in sites with varying endemicities in Kinshasa Province, Democratic Republic of the Congo Mwandagalirwa, Melchior Kashamuka Levitz, Lauren Thwai, Kyaw L. Parr, Jonathan B. Goel, Varun Janko, Mark Tshefu, Antoinette Emch, Michael Meshnick, Steven R. Carrel, Margaret Malar J Research BACKGROUND: The Democratic Republic of the Congo (DRC) bears a large share of global malaria burden despite efforts to control and eliminate the disease. More detailed understanding of individual and household level characteristics associated with malaria are needed, as is an understanding of how these characteristics vary spatiotemporally and across different community-level malaria endemicities. An ongoing study in Kinshasa Province is designed to address gaps in prior malaria surveillance in the DRC by monitoring malaria across seasons, age groups and in high and low malaria sites. Across seven sites, 242 households and 1591 individuals are participating in the study. Results of the enrollment questionnaire, rapid diagnostic tests and PCR testing of dried blood spots are presented. RESULTS: Overall malaria prevalence in the study cohort is high, 27% by rapid diagnostic test and 31% by polymerase chain reaction, and malaria prevalence is highly varied across very small geographic distances. Malaria prevalence is highest in children aged 6–15. While the majority of households own bed nets, bed net usage is less than 50%. CONCLUSIONS: The study cohort will provide an understanding of how malaria persists in populations that have varying environmental exposures, varying community-level malaria, and varying access to malaria control efforts. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12936-017-2110-7) contains supplementary material, which is available to authorized users. BioMed Central 2017-11-09 /pmc/articles/PMC5680818/ /pubmed/29121931 http://dx.doi.org/10.1186/s12936-017-2110-7 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Mwandagalirwa, Melchior Kashamuka
Levitz, Lauren
Thwai, Kyaw L.
Parr, Jonathan B.
Goel, Varun
Janko, Mark
Tshefu, Antoinette
Emch, Michael
Meshnick, Steven R.
Carrel, Margaret
Individual and household characteristics of persons with Plasmodium falciparum malaria in sites with varying endemicities in Kinshasa Province, Democratic Republic of the Congo
title Individual and household characteristics of persons with Plasmodium falciparum malaria in sites with varying endemicities in Kinshasa Province, Democratic Republic of the Congo
title_full Individual and household characteristics of persons with Plasmodium falciparum malaria in sites with varying endemicities in Kinshasa Province, Democratic Republic of the Congo
title_fullStr Individual and household characteristics of persons with Plasmodium falciparum malaria in sites with varying endemicities in Kinshasa Province, Democratic Republic of the Congo
title_full_unstemmed Individual and household characteristics of persons with Plasmodium falciparum malaria in sites with varying endemicities in Kinshasa Province, Democratic Republic of the Congo
title_short Individual and household characteristics of persons with Plasmodium falciparum malaria in sites with varying endemicities in Kinshasa Province, Democratic Republic of the Congo
title_sort individual and household characteristics of persons with plasmodium falciparum malaria in sites with varying endemicities in kinshasa province, democratic republic of the congo
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680818/
https://www.ncbi.nlm.nih.gov/pubmed/29121931
http://dx.doi.org/10.1186/s12936-017-2110-7
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